Residential proximity to industrial combustion facilities and risk of non-Hodgkin lymphoma: A case-control study

Anjoeka Pronk, John R. Nuckols, Anneclaire J. De Roos, Matthew Airola, Joanne S. Colt, James R Cerhan, Lindsay Morton, Wendy Cozen, Richard Severson, Aaron Blair, David Cleverly, Mary H. Ward

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Residence near municipal solid waste incinerators, a major historical source of dioxin emissions, has been associated with increased risk of non-Hodgkin lymphoma (NHL) in European studies. The aim of our study was to evaluate residence near industrial combustion facilities and estimates of dioxin emissions in relation to NHL risk in the United States. Methods. We conducted a population-based case-control study of NHL (1998-2000) in four National Cancer Institute-Surveillance Epidemiology and End Results centers (Detroit, Iowa, Los Angeles, Seattle). Residential histories 15 years before diagnosis (similar date for controls) were linked to an Environmental Protection Agency database of dioxin-emitting facilities for 969 cases and 749 controls. We evaluated proximity (3 and 5 km) to 10 facility types that accounted for >85% of U.S. emissions and a distance-weighted average emission index (AEI [ng toxic equivalency quotient (TEQ)/year]). Results: Proximity to any dioxin-emitting facility was not associated with NHL risk (3 km OR=1.0, 95% CI 0.8-1.3). Risk was elevated for residence near cement kilns (5 km OR=1.7, 95% CI 0.8-3.3; 3 km OR=3.8, 95% CI 1.1-14.0) and reduced for residence near municipal solid waste incinerators (5 km OR=0.5, 95% CI 0.3-0.9; 3 km OR=0.3, 95% CI 0.1-1.4). The AEI was not associated with risk of NHL overall. Risk for marginal zone lymphoma was increased for the highest versus lowest quartile (5 km OR=2.6, 95% CI 1.0-6.8; 3 km OR=3.0, 95% CI 1.1-8.3). Conclusions: Overall, we found no association with residential exposure to dioxins and NHL risk. However, findings for high emissions and marginal zone lymphoma and for specific facility types and all NHL provide some evidence of an association and deserve future study.

Original languageEnglish (US)
Article number20
JournalEnvironmental Health: A Global Access Science Source
Volume12
Issue number1
DOIs
StatePublished - 2013

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Non-Hodgkin's Lymphoma
Case-Control Studies
Dioxins
Solid Waste
Lymphoma
United States Environmental Protection Agency
Los Angeles
National Cancer Institute (U.S.)
Poisons
Manufacturing and Industrial Facilities
Epidemiology
Databases
Population

Keywords

  • Air pollution
  • Case-control study
  • Dioxins
  • Geographic information systems
  • Lymphomas
  • Non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Residential proximity to industrial combustion facilities and risk of non-Hodgkin lymphoma : A case-control study. / Pronk, Anjoeka; Nuckols, John R.; De Roos, Anneclaire J.; Airola, Matthew; Colt, Joanne S.; Cerhan, James R; Morton, Lindsay; Cozen, Wendy; Severson, Richard; Blair, Aaron; Cleverly, David; Ward, Mary H.

In: Environmental Health: A Global Access Science Source, Vol. 12, No. 1, 20, 2013.

Research output: Contribution to journalArticle

Pronk, A, Nuckols, JR, De Roos, AJ, Airola, M, Colt, JS, Cerhan, JR, Morton, L, Cozen, W, Severson, R, Blair, A, Cleverly, D & Ward, MH 2013, 'Residential proximity to industrial combustion facilities and risk of non-Hodgkin lymphoma: A case-control study', Environmental Health: A Global Access Science Source, vol. 12, no. 1, 20. https://doi.org/10.1186/1476-069X-12-20
Pronk, Anjoeka ; Nuckols, John R. ; De Roos, Anneclaire J. ; Airola, Matthew ; Colt, Joanne S. ; Cerhan, James R ; Morton, Lindsay ; Cozen, Wendy ; Severson, Richard ; Blair, Aaron ; Cleverly, David ; Ward, Mary H. / Residential proximity to industrial combustion facilities and risk of non-Hodgkin lymphoma : A case-control study. In: Environmental Health: A Global Access Science Source. 2013 ; Vol. 12, No. 1.
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abstract = "Background: Residence near municipal solid waste incinerators, a major historical source of dioxin emissions, has been associated with increased risk of non-Hodgkin lymphoma (NHL) in European studies. The aim of our study was to evaluate residence near industrial combustion facilities and estimates of dioxin emissions in relation to NHL risk in the United States. Methods. We conducted a population-based case-control study of NHL (1998-2000) in four National Cancer Institute-Surveillance Epidemiology and End Results centers (Detroit, Iowa, Los Angeles, Seattle). Residential histories 15 years before diagnosis (similar date for controls) were linked to an Environmental Protection Agency database of dioxin-emitting facilities for 969 cases and 749 controls. We evaluated proximity (3 and 5 km) to 10 facility types that accounted for >85{\%} of U.S. emissions and a distance-weighted average emission index (AEI [ng toxic equivalency quotient (TEQ)/year]). Results: Proximity to any dioxin-emitting facility was not associated with NHL risk (3 km OR=1.0, 95{\%} CI 0.8-1.3). Risk was elevated for residence near cement kilns (5 km OR=1.7, 95{\%} CI 0.8-3.3; 3 km OR=3.8, 95{\%} CI 1.1-14.0) and reduced for residence near municipal solid waste incinerators (5 km OR=0.5, 95{\%} CI 0.3-0.9; 3 km OR=0.3, 95{\%} CI 0.1-1.4). The AEI was not associated with risk of NHL overall. Risk for marginal zone lymphoma was increased for the highest versus lowest quartile (5 km OR=2.6, 95{\%} CI 1.0-6.8; 3 km OR=3.0, 95{\%} CI 1.1-8.3). Conclusions: Overall, we found no association with residential exposure to dioxins and NHL risk. However, findings for high emissions and marginal zone lymphoma and for specific facility types and all NHL provide some evidence of an association and deserve future study.",
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AU - Nuckols, John R.

AU - De Roos, Anneclaire J.

AU - Airola, Matthew

AU - Colt, Joanne S.

AU - Cerhan, James R

AU - Morton, Lindsay

AU - Cozen, Wendy

AU - Severson, Richard

AU - Blair, Aaron

AU - Cleverly, David

AU - Ward, Mary H.

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N2 - Background: Residence near municipal solid waste incinerators, a major historical source of dioxin emissions, has been associated with increased risk of non-Hodgkin lymphoma (NHL) in European studies. The aim of our study was to evaluate residence near industrial combustion facilities and estimates of dioxin emissions in relation to NHL risk in the United States. Methods. We conducted a population-based case-control study of NHL (1998-2000) in four National Cancer Institute-Surveillance Epidemiology and End Results centers (Detroit, Iowa, Los Angeles, Seattle). Residential histories 15 years before diagnosis (similar date for controls) were linked to an Environmental Protection Agency database of dioxin-emitting facilities for 969 cases and 749 controls. We evaluated proximity (3 and 5 km) to 10 facility types that accounted for >85% of U.S. emissions and a distance-weighted average emission index (AEI [ng toxic equivalency quotient (TEQ)/year]). Results: Proximity to any dioxin-emitting facility was not associated with NHL risk (3 km OR=1.0, 95% CI 0.8-1.3). Risk was elevated for residence near cement kilns (5 km OR=1.7, 95% CI 0.8-3.3; 3 km OR=3.8, 95% CI 1.1-14.0) and reduced for residence near municipal solid waste incinerators (5 km OR=0.5, 95% CI 0.3-0.9; 3 km OR=0.3, 95% CI 0.1-1.4). The AEI was not associated with risk of NHL overall. Risk for marginal zone lymphoma was increased for the highest versus lowest quartile (5 km OR=2.6, 95% CI 1.0-6.8; 3 km OR=3.0, 95% CI 1.1-8.3). Conclusions: Overall, we found no association with residential exposure to dioxins and NHL risk. However, findings for high emissions and marginal zone lymphoma and for specific facility types and all NHL provide some evidence of an association and deserve future study.

AB - Background: Residence near municipal solid waste incinerators, a major historical source of dioxin emissions, has been associated with increased risk of non-Hodgkin lymphoma (NHL) in European studies. The aim of our study was to evaluate residence near industrial combustion facilities and estimates of dioxin emissions in relation to NHL risk in the United States. Methods. We conducted a population-based case-control study of NHL (1998-2000) in four National Cancer Institute-Surveillance Epidemiology and End Results centers (Detroit, Iowa, Los Angeles, Seattle). Residential histories 15 years before diagnosis (similar date for controls) were linked to an Environmental Protection Agency database of dioxin-emitting facilities for 969 cases and 749 controls. We evaluated proximity (3 and 5 km) to 10 facility types that accounted for >85% of U.S. emissions and a distance-weighted average emission index (AEI [ng toxic equivalency quotient (TEQ)/year]). Results: Proximity to any dioxin-emitting facility was not associated with NHL risk (3 km OR=1.0, 95% CI 0.8-1.3). Risk was elevated for residence near cement kilns (5 km OR=1.7, 95% CI 0.8-3.3; 3 km OR=3.8, 95% CI 1.1-14.0) and reduced for residence near municipal solid waste incinerators (5 km OR=0.5, 95% CI 0.3-0.9; 3 km OR=0.3, 95% CI 0.1-1.4). The AEI was not associated with risk of NHL overall. Risk for marginal zone lymphoma was increased for the highest versus lowest quartile (5 km OR=2.6, 95% CI 1.0-6.8; 3 km OR=3.0, 95% CI 1.1-8.3). Conclusions: Overall, we found no association with residential exposure to dioxins and NHL risk. However, findings for high emissions and marginal zone lymphoma and for specific facility types and all NHL provide some evidence of an association and deserve future study.

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KW - Geographic information systems

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KW - Non-Hodgkin lymphoma

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