Resective reoperation for failed epilepsy surgery: Seizure outcome in 64 patients

A. M. Siegel, Gregory D Cascino, F. B. Meyer, R. L. McClelland, E. L. So, W. R. Marsh, B. W. Scheithauer, F. W. Sharbrough

Research output: Contribution to journalArticle

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Abstract

Objective: To determine the surgical outcome and factors of predictive value in patients undergoing reoperation for intractable partial epilepsy. Methods: The authors retrospectively studied the operative outcome in 64 consecutive patients who underwent reoperation for intractable partial epilepsy. Demographic data, results of comprehensive preoperative evaluations, and the seizure and neurologic outcome after reoperation were determined. All patients were followed a minimum of 1 year subsequent to their last operative procedure. Results: Fifty-three patients had two surgeries, and 11 patients had three or more operations. The first surgery involved a lesionectomy (n = 33), "nonlesional" temporal lobe resection (n = 28), and a "nonlesional" extratemporal resection (n = 3). The mean duration between the first and second procedure was 5.5 years. Fifty-five patients underwent an intralobar reoperation, whereas nine had a resection of a different lobe. After reoperation, 25 patients (39%) were free of seizure, 6 patients (9%) had rare seizures, 12 patients (19%) had a worthwhile improvement, and 21 patients (33%) failed to respond to surgery. Predictors of seizure-free outcome were age at seizure onset >15 years (p = 0.01), duration of epilepsy ≤5 years at the time of initial surgery (p = 0.03), and focal interictal discharges in scalp EEG (p = 0.03). Using a logistic regression model, two significant predictors emerged: duration of epilepsy ≤5 years (odds ratio, 3.18; p = 0.04) and preoperative focal interictal discharge (odds ratio, 4.45; p = 0.02). Complications of reoperation included visual field deficits (n = 9), wound infection (n = 2), subdural hematoma (n = 1), and hemiparesis (n = 1). Conclusion: Reoperation may be an appropriate alternative form of treatment for selected patients with intractable partial epilepsy who fail to respond to initial surgery.

Original languageEnglish (US)
Pages (from-to)2298-2302
Number of pages5
JournalNeurology
Volume63
Issue number12
StatePublished - Dec 28 2004

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Reoperation
Epilepsy
Seizures
Partial Epilepsy
Logistic Models
Odds Ratio
Subdural Hematoma
Operative Surgical Procedures
Paresis
Wound Infection
Temporal Lobe
Scalp
Visual Fields
Age of Onset
Nervous System
Electroencephalography
Demography

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Siegel, A. M., Cascino, G. D., Meyer, F. B., McClelland, R. L., So, E. L., Marsh, W. R., ... Sharbrough, F. W. (2004). Resective reoperation for failed epilepsy surgery: Seizure outcome in 64 patients. Neurology, 63(12), 2298-2302.

Resective reoperation for failed epilepsy surgery : Seizure outcome in 64 patients. / Siegel, A. M.; Cascino, Gregory D; Meyer, F. B.; McClelland, R. L.; So, E. L.; Marsh, W. R.; Scheithauer, B. W.; Sharbrough, F. W.

In: Neurology, Vol. 63, No. 12, 28.12.2004, p. 2298-2302.

Research output: Contribution to journalArticle

Siegel, AM, Cascino, GD, Meyer, FB, McClelland, RL, So, EL, Marsh, WR, Scheithauer, BW & Sharbrough, FW 2004, 'Resective reoperation for failed epilepsy surgery: Seizure outcome in 64 patients', Neurology, vol. 63, no. 12, pp. 2298-2302.
Siegel AM, Cascino GD, Meyer FB, McClelland RL, So EL, Marsh WR et al. Resective reoperation for failed epilepsy surgery: Seizure outcome in 64 patients. Neurology. 2004 Dec 28;63(12):2298-2302.
Siegel, A. M. ; Cascino, Gregory D ; Meyer, F. B. ; McClelland, R. L. ; So, E. L. ; Marsh, W. R. ; Scheithauer, B. W. ; Sharbrough, F. W. / Resective reoperation for failed epilepsy surgery : Seizure outcome in 64 patients. In: Neurology. 2004 ; Vol. 63, No. 12. pp. 2298-2302.
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T2 - Seizure outcome in 64 patients

AU - Siegel, A. M.

AU - Cascino, Gregory D

AU - Meyer, F. B.

AU - McClelland, R. L.

AU - So, E. L.

AU - Marsh, W. R.

AU - Scheithauer, B. W.

AU - Sharbrough, F. W.

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N2 - Objective: To determine the surgical outcome and factors of predictive value in patients undergoing reoperation for intractable partial epilepsy. Methods: The authors retrospectively studied the operative outcome in 64 consecutive patients who underwent reoperation for intractable partial epilepsy. Demographic data, results of comprehensive preoperative evaluations, and the seizure and neurologic outcome after reoperation were determined. All patients were followed a minimum of 1 year subsequent to their last operative procedure. Results: Fifty-three patients had two surgeries, and 11 patients had three or more operations. The first surgery involved a lesionectomy (n = 33), "nonlesional" temporal lobe resection (n = 28), and a "nonlesional" extratemporal resection (n = 3). The mean duration between the first and second procedure was 5.5 years. Fifty-five patients underwent an intralobar reoperation, whereas nine had a resection of a different lobe. After reoperation, 25 patients (39%) were free of seizure, 6 patients (9%) had rare seizures, 12 patients (19%) had a worthwhile improvement, and 21 patients (33%) failed to respond to surgery. Predictors of seizure-free outcome were age at seizure onset >15 years (p = 0.01), duration of epilepsy ≤5 years at the time of initial surgery (p = 0.03), and focal interictal discharges in scalp EEG (p = 0.03). Using a logistic regression model, two significant predictors emerged: duration of epilepsy ≤5 years (odds ratio, 3.18; p = 0.04) and preoperative focal interictal discharge (odds ratio, 4.45; p = 0.02). Complications of reoperation included visual field deficits (n = 9), wound infection (n = 2), subdural hematoma (n = 1), and hemiparesis (n = 1). Conclusion: Reoperation may be an appropriate alternative form of treatment for selected patients with intractable partial epilepsy who fail to respond to initial surgery.

AB - Objective: To determine the surgical outcome and factors of predictive value in patients undergoing reoperation for intractable partial epilepsy. Methods: The authors retrospectively studied the operative outcome in 64 consecutive patients who underwent reoperation for intractable partial epilepsy. Demographic data, results of comprehensive preoperative evaluations, and the seizure and neurologic outcome after reoperation were determined. All patients were followed a minimum of 1 year subsequent to their last operative procedure. Results: Fifty-three patients had two surgeries, and 11 patients had three or more operations. The first surgery involved a lesionectomy (n = 33), "nonlesional" temporal lobe resection (n = 28), and a "nonlesional" extratemporal resection (n = 3). The mean duration between the first and second procedure was 5.5 years. Fifty-five patients underwent an intralobar reoperation, whereas nine had a resection of a different lobe. After reoperation, 25 patients (39%) were free of seizure, 6 patients (9%) had rare seizures, 12 patients (19%) had a worthwhile improvement, and 21 patients (33%) failed to respond to surgery. Predictors of seizure-free outcome were age at seizure onset >15 years (p = 0.01), duration of epilepsy ≤5 years at the time of initial surgery (p = 0.03), and focal interictal discharges in scalp EEG (p = 0.03). Using a logistic regression model, two significant predictors emerged: duration of epilepsy ≤5 years (odds ratio, 3.18; p = 0.04) and preoperative focal interictal discharge (odds ratio, 4.45; p = 0.02). Complications of reoperation included visual field deficits (n = 9), wound infection (n = 2), subdural hematoma (n = 1), and hemiparesis (n = 1). Conclusion: Reoperation may be an appropriate alternative form of treatment for selected patients with intractable partial epilepsy who fail to respond to initial surgery.

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