Resective reoperation for failed epilepsy surgery: Seizure outcome in 64 patients

A. M. Siegel, G. D. Cascino, F. B. Meyer, R. L. McClelland, E. L. So, W. R. Marsh, B. W. Scheithauer, F. W. Sharbrough

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Objective: To determine the surgical outcome and factors of predictive value in patients undergoing reoperation for intractable partial epilepsy. Methods: The authors retrospectively studied the operative outcome in 64 consecutive patients who underwent reoperation for intractable partial epilepsy. Demographic data, results of comprehensive preoperative evaluations, and the seizure and neurologic outcome after reoperation were determined. All patients were followed a minimum of 1 year subsequent to their last operative procedure. Results: Fifty-three patients had two surgeries, and 11 patients had three or more operations. The first surgery involved a lesionectomy (n = 33), "nonlesional" temporal lobe resection (n = 28), and a "nonlesional" extratemporal resection (n = 3). The mean duration between the first and second procedure was 5.5 years. Fifty-five patients underwent an intralobar reoperation, whereas nine had a resection of a different lobe. After reoperation, 25 patients (39%) were free of seizure, 6 patients (9%) had rare seizures, 12 patients (19%) had a worthwhile improvement, and 21 patients (33%) failed to respond to surgery. Predictors of seizure-free outcome were age at seizure onset >15 years (p = 0.01), duration of epilepsy ≤5 years at the time of initial surgery (p = 0.03), and focal interictal discharges in scalp EEG (p = 0.03). Using a logistic regression model, two significant predictors emerged: duration of epilepsy ≤5 years (odds ratio, 3.18; p = 0.04) and preoperative focal interictal discharge (odds ratio, 4.45; p = 0.02). Complications of reoperation included visual field deficits (n = 9), wound infection (n = 2), subdural hematoma (n = 1), and hemiparesis (n = 1). Conclusion: Reoperation may be an appropriate alternative form of treatment for selected patients with intractable partial epilepsy who fail to respond to initial surgery.

Original languageEnglish (US)
Pages (from-to)2298-2302
Number of pages5
JournalNeurology
Volume63
Issue number12
DOIs
StatePublished - Dec 28 2004

ASJC Scopus subject areas

  • Clinical Neurology

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    Siegel, A. M., Cascino, G. D., Meyer, F. B., McClelland, R. L., So, E. L., Marsh, W. R., Scheithauer, B. W., & Sharbrough, F. W. (2004). Resective reoperation for failed epilepsy surgery: Seizure outcome in 64 patients. Neurology, 63(12), 2298-2302. https://doi.org/10.1212/01.WNL.0000147476.86575.A7