Research criteria for the diagnosis of prodromal dementia with Lewy bodies

Ian G. McKeith, Tanis J. Ferman, Alan J. Thomas, Frédéric Blanc, Bradley F. Boeve, Hiroshige Fujishiro, Kejal Kantarci, Cristina Muscio, John T. O'Brien, Ronald B. Postuma, Dag Aarsland, Clive Ballard, Laura Bonanni, Paul Donaghy, Murat Emre, James E. Galvin, Douglas Galasko, Jennifer G. Goldman, Stephen N. Gomperts, Lawrence S. HonigManabu Ikeda, James B. Leverenz, Simon J.G. Lewis, Karen S. Marder, Mario Masellis, David P. Salmon, John Paul Taylor, Debby W. Tsuang, Zuzana Walker, Pietro Tiraboschi

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive impairment (MCI), (2) delirium-onset, and (3) psychiatric-onset presentations. The purpose of our review is to determine whether there is sufficient information yet available to justify development of diagnostic criteria for each of these. Our goal is to achieve evidence-based recommendations for the recognition of DLB at a predementia, symptomatic stage. We propose operationalized diagnostic criteria for probable and possible mild cognitive impairment with Lewy bodies, which are intended for use in research settings pending validation for use in clinical practice. They are compatible with current criteria for other prodromal neurodegenerative disorders including Alzheimer and Parkinson disease. Although there is still insufficient evidence to propose formal criteria for delirium-onset and psychiatric-onset presentations of DLB, we feel that it is important to characterize them, raising the index of diagnostic suspicion and prioritizing them for further investigation.

Original languageEnglish (US)
Pages (from-to)743-755
Number of pages13
JournalNeurology
Volume94
Issue number17
DOIs
StatePublished - Apr 28 2020

ASJC Scopus subject areas

  • Clinical Neurology

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    McKeith, I. G., Ferman, T. J., Thomas, A. J., Blanc, F., Boeve, B. F., Fujishiro, H., Kantarci, K., Muscio, C., O'Brien, J. T., Postuma, R. B., Aarsland, D., Ballard, C., Bonanni, L., Donaghy, P., Emre, M., Galvin, J. E., Galasko, D., Goldman, J. G., Gomperts, S. N., ... Tiraboschi, P. (2020). Research criteria for the diagnosis of prodromal dementia with Lewy bodies. Neurology, 94(17), 743-755. https://doi.org/10.1212/WNL.0000000000009323