Report of the ECCO workshop on anti-TNF therapy failures in inflammatory bowel diseases: Biological roles and effects of TNF and TNF antagonists

Yehuda Chowers, Andreas Sturm, Miquel Sans, Konstantinos Papadakis, Maria Gazouli, Marcus Harbord, Jörg Jahnel, Gerassimos J. Mantzaris, Johannes Meier, Christian Mottet, Laurent Peyrin-Biroulet, Matthieu Allez

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

This second section of the first ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases addresses the biological roles of TNFα and the effects and mechanisms of action of TNFα antagonists. Mechanisms underlying their failure, including induction of TNF-independent inflammatory pathways and phenomena of paradoxical inflammation are discussed.

Original languageEnglish (US)
Pages (from-to)367-376
Number of pages10
JournalJournal of Crohn's and Colitis
Volume4
Issue number4
DOIs
StatePublished - Oct 1 2010

Keywords

  • Anti-TNF therapy
  • Crohn's disease
  • Inflammatory bowel diseases
  • Paradoxical inflammation
  • TNF alpha
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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    Chowers, Y., Sturm, A., Sans, M., Papadakis, K., Gazouli, M., Harbord, M., Jahnel, J., Mantzaris, G. J., Meier, J., Mottet, C., Peyrin-Biroulet, L., & Allez, M. (2010). Report of the ECCO workshop on anti-TNF therapy failures in inflammatory bowel diseases: Biological roles and effects of TNF and TNF antagonists. Journal of Crohn's and Colitis, 4(4), 367-376. https://doi.org/10.1016/j.crohns.2010.05.011