Renal LECT2 amyloidosis: A newly described disorder gaining greater recognition

Andrew Kowalski, Julio Cabrera, Samih Nasr, Edgar Lerma

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Amyloidosis results from the pathologic deposition of beta pleated sheet fibrils within various organs including the kidney. Most often, the deposition is composed of the well-known monoclonal immunoglobulin light chains (AL) or serum amyloid A protein (AA). Recently, a new type of amyloidogenic protein was discovered, leukocyte chemotactic factor 2 (LECT2). This type of amyloid tends to have an affinity to kidney and liver and is recognized as a distinct clinico-pathologic type of amyloidosis, presenting with varying degrees of impaired kidney function and proteinuria. Herein, a case of this uncommon novel amyloidosis is presented with a brief review of the literature.

Original languageEnglish (US)
Pages (from-to)236-240
Number of pages5
JournalClinical Nephrology
Volume84
Issue number4
DOIs
StatePublished - 2015

Keywords

  • ALECT2
  • Amyloidosis
  • LECT2
  • Leucozyte chemotactic factor 2
  • Renal amyloidosis

ASJC Scopus subject areas

  • Nephrology

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