Renal-endocrine adaptations to endogenous atrial natriuretic factor during tachycardia-induced reductions in renal perfusion pressure

W. L. Miller, B. S. Edwards, R. S. Zimmerman, J. C. Burnett

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Atrial pressure, atrial natriuretic factor (ANF), the renin-angiotensin-aldosterone system, and renal hemodynamic functions were examined during and after right ventricular pacing in anesthetized dogs (n = 9). Mean arterial pressure, cardiac output, and renal blood flow decreased during tachycardia while right and left atrial pressures increased. ANF markedly increased during tachycardia but urinary and fractional excretion of sodium were unchanged from control. Plasma renin activity was not increased during pacing despite the decrease in renal perfusion pressure. After tachycardia and restoration of mean arterial pressure to control, ANF declined but remained elevated above control despite a return of atrial pressure to control level. After tachycardia, urinary and fractional sodium excretion increased significantly in the absence of an increase in glomerular filtration rate. These findings support the following conclusions: 1) tachycardia increases ANF in association with increased atrial pressure; however, an elevation of ANF persists following tachycardia despite the absence of the persistent stimulus of elevated atrial pressures; 2) the increase in ANF during tachycardia may contribute to the absence of a decrease in sodium excretion and activation of the renin-angiotensin system that occurs with reduction in renal perfusion pressure; and 3) tachycardia-induced natriuresis may be dependent on an increase in ANF and the maintenance of renal perfusion pressure.

Original languageEnglish (US)
Pages (from-to)76-83
Number of pages8
JournalCirculation research
Volume66
Issue number1
DOIs
StatePublished - 1990

Keywords

  • atrial natriuretic factor
  • renal perfusion pressure
  • renin-angiotensin-aldosterone system
  • sodium excretion
  • tachycardia
  • ventricular pacing

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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