Renal cell-urinary crystal interactions

John C Lieske, F. Gary Toback

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Crystals of calcium oxalate and calcium phosphate bind to anionic molecules on the apical surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate directly on the plasma membrane. The internalization of adherent crystals, changes in gene expression, and secretion of specific proteins ensue, and appear to be important processes in crystal retention and kidney stone pathogenesis. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)349-355
Number of pages7
JournalCurrent Opinion in Nephrology and Hypertension
Volume9
Issue number4
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Kidney
Calcium Oxalate
Kidney Calculi
Anions
Cell Membrane
Gene Expression
Proteins
calcium phosphate

ASJC Scopus subject areas

  • Nephrology
  • Internal Medicine

Cite this

Renal cell-urinary crystal interactions. / Lieske, John C; Toback, F. Gary.

In: Current Opinion in Nephrology and Hypertension, Vol. 9, No. 4, 2000, p. 349-355.

Research output: Contribution to journalArticle

@article{b10247def0c148b4a0e7a644d811fca8,
title = "Renal cell-urinary crystal interactions",
abstract = "Crystals of calcium oxalate and calcium phosphate bind to anionic molecules on the apical surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate directly on the plasma membrane. The internalization of adherent crystals, changes in gene expression, and secretion of specific proteins ensue, and appear to be important processes in crystal retention and kidney stone pathogenesis. (C) 2000 Lippincott Williams and Wilkins.",
author = "Lieske, {John C} and Toback, {F. Gary}",
year = "2000",
doi = "10.1097/00041552-200007000-00005",
language = "English (US)",
volume = "9",
pages = "349--355",
journal = "Current Opinion in Nephrology and Hypertension",
issn = "1062-4821",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Renal cell-urinary crystal interactions

AU - Lieske, John C

AU - Toback, F. Gary

PY - 2000

Y1 - 2000

N2 - Crystals of calcium oxalate and calcium phosphate bind to anionic molecules on the apical surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate directly on the plasma membrane. The internalization of adherent crystals, changes in gene expression, and secretion of specific proteins ensue, and appear to be important processes in crystal retention and kidney stone pathogenesis. (C) 2000 Lippincott Williams and Wilkins.

AB - Crystals of calcium oxalate and calcium phosphate bind to anionic molecules on the apical surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate directly on the plasma membrane. The internalization of adherent crystals, changes in gene expression, and secretion of specific proteins ensue, and appear to be important processes in crystal retention and kidney stone pathogenesis. (C) 2000 Lippincott Williams and Wilkins.

UR - http://www.scopus.com/inward/record.url?scp=0033921456&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033921456&partnerID=8YFLogxK

U2 - 10.1097/00041552-200007000-00005

DO - 10.1097/00041552-200007000-00005

M3 - Article

VL - 9

SP - 349

EP - 355

JO - Current Opinion in Nephrology and Hypertension

JF - Current Opinion in Nephrology and Hypertension

SN - 1062-4821

IS - 4

ER -