REM sleep behavior disorder in Parkinson's disease and dementia with Lewy bodies

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep. Patients appear to "act out their dreams," in which the exhibited behaviors mirror the content of the dreams. Management of RBD involves counseling about safety measures in the sleep environment; in those at risk for injury, clonazepam and/or melatonin is usually effective. In this article, the authors present a detailed review of the clinical and polysomnographic features, differential diagnosis, diagnostic criteria, management strategies, and pathophysiologic mechanisms of RBD. They then review the literature and their institutional experience of RBD associated with neurodegenerative disease, particularly Parkinson's disease and dementia with Lewy bodies. The evolving data suggests that RBD may have clinical diagnostic and pathophysiologic significance in isolation and when associated with neurodegenerative disease.

Original languageEnglish (US)
Pages (from-to)146-157
Number of pages12
JournalJournal of Geriatric Psychiatry and Neurology
Volume17
Issue number3
DOIs
StatePublished - Sep 2004

Fingerprint

REM Sleep Behavior Disorder
Lewy Body Disease
Parkinson Disease
Neurodegenerative Diseases
Sleep
Parasomnias
Clonazepam
REM Sleep
Melatonin
Counseling
Differential Diagnosis
Safety
Wounds and Injuries

Keywords

  • Dementia with Lewy bodies
  • Parkinson's disease
  • REM sleep behavior disorder
  • Synuclein
  • Synucleinopathy

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology
  • Neuroscience(all)

Cite this

REM sleep behavior disorder in Parkinson's disease and dementia with Lewy bodies. / Boeve, Bradley F; Silber, Michael H.; Ferman, Tanis Jill.

In: Journal of Geriatric Psychiatry and Neurology, Vol. 17, No. 3, 09.2004, p. 146-157.

Research output: Contribution to journalArticle

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