Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element

Andrew P. Norgan; Brian A. Davies; Ishara F. Azmi; Andreas S. Schroeder; Johanna A. Payne; Gregory M. Lynch; Zhaohui Xu; David J. Katzmann

doi:10.1074/jbc.M113.494112

Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element

Andrew P. Norgan, Brian A. Davies, Ishara F. Azmi, Andreas S. Schroeder, Johanna A. Payne, Gregory M. Lynch, Zhaohui Xu, David J. Katzmann

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: Vta1 promotes Vps4 ATPase activity and facilitates ESCRT-III stimulation of Vps4. Results: The Vta1 VSE (Vps4 stimulatory element) mediates ESCRT-III-enhanced activation of Vps4 and contributes to Vta1 function in vivo. Conclusion: ESCRT-III binding Vta1 relieves autoinhibition of the VSE to promote activation of Vps4. Significance: These studies identify a novel mechanism whereby ESCRT-III and Vta1 regulate Vps4 activity.

Original language	English (US)
Pages (from-to)	26147-26156
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M113.494112
State	Published - Sep 6 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M113.494112

Cite this

@article{e48a255be011460b9892d5d52445a7bf,

title = "Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element",

abstract = "Background: Vta1 promotes Vps4 ATPase activity and facilitates ESCRT-III stimulation of Vps4. Results: The Vta1 VSE (Vps4 stimulatory element) mediates ESCRT-III-enhanced activation of Vps4 and contributes to Vta1 function in vivo. Conclusion: ESCRT-III binding Vta1 relieves autoinhibition of the VSE to promote activation of Vps4. Significance: These studies identify a novel mechanism whereby ESCRT-III and Vta1 regulate Vps4 activity.",

author = "Norgan, {Andrew P.} and Davies, {Brian A.} and Azmi, {Ishara F.} and Schroeder, {Andreas S.} and Payne, {Johanna A.} and Lynch, {Gregory M.} and Zhaohui Xu and Katzmann, {David J.}",

year = "2013",

month = sep,

day = "6",

doi = "10.1074/jbc.M113.494112",

language = "English (US)",

volume = "288",

pages = "26147--26156",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "36",

}

TY - JOUR

T1 - Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element

AU - Norgan, Andrew P.

AU - Davies, Brian A.

AU - Azmi, Ishara F.

AU - Schroeder, Andreas S.

AU - Payne, Johanna A.

AU - Lynch, Gregory M.

AU - Xu, Zhaohui

AU - Katzmann, David J.

PY - 2013/9/6

Y1 - 2013/9/6

N2 - Background: Vta1 promotes Vps4 ATPase activity and facilitates ESCRT-III stimulation of Vps4. Results: The Vta1 VSE (Vps4 stimulatory element) mediates ESCRT-III-enhanced activation of Vps4 and contributes to Vta1 function in vivo. Conclusion: ESCRT-III binding Vta1 relieves autoinhibition of the VSE to promote activation of Vps4. Significance: These studies identify a novel mechanism whereby ESCRT-III and Vta1 regulate Vps4 activity.

AB - Background: Vta1 promotes Vps4 ATPase activity and facilitates ESCRT-III stimulation of Vps4. Results: The Vta1 VSE (Vps4 stimulatory element) mediates ESCRT-III-enhanced activation of Vps4 and contributes to Vta1 function in vivo. Conclusion: ESCRT-III binding Vta1 relieves autoinhibition of the VSE to promote activation of Vps4. Significance: These studies identify a novel mechanism whereby ESCRT-III and Vta1 regulate Vps4 activity.

UR - http://www.scopus.com/inward/record.url?scp=84883720423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883720423&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.494112

DO - 10.1074/jbc.M113.494112

M3 - Article

C2 - 23880759

AN - SCOPUS:84883720423

SN - 0021-9258

VL - 288

SP - 26147

EP - 26156

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 36

ER -

Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this