Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element

Andrew P. Norgan, Brian A. Davies, Ishara F. Azmi, Andreas S. Schroeder, Johanna A. Payne, Gregory M. Lynch, Zhaohui Xu, David J. Katzmann

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: Vta1 promotes Vps4 ATPase activity and facilitates ESCRT-III stimulation of Vps4. Results: The Vta1 VSE (Vps4 stimulatory element) mediates ESCRT-III-enhanced activation of Vps4 and contributes to Vta1 function in vivo. Conclusion: ESCRT-III binding Vta1 relieves autoinhibition of the VSE to promote activation of Vps4. Significance: These studies identify a novel mechanism whereby ESCRT-III and Vta1 regulate Vps4 activity.

Original languageEnglish (US)
Pages (from-to)26147-26156
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number36
DOIs
StatePublished - Sep 6 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Norgan, A. P., Davies, B. A., Azmi, I. F., Schroeder, A. S., Payne, J. A., Lynch, G. M., Xu, Z., & Katzmann, D. J. (2013). Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element. Journal of Biological Chemistry, 288(36), 26147-26156. https://doi.org/10.1074/jbc.M113.494112