Release kinetics of rhBMP-2 from PLGA microspheres embedded in a porous poly (propylene fumarate) scaffold

E. Jabbari, A. V. Florschutz, L. G. Pedersen, N. Liu, Lichun Lu, B. L. Currier, Michael J Yaszemski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

The release characteristics of human recombinant bone morphogenetic protein-2 (rh-BMP-2) from PLGA microspheres embedded in a porous poly(propylene furamate) (PPF) scaffold was investigated. PLGA with lactide to glycolide ratio and weight average molecular weight of 25 or 60 kg/mol was used for microsphere preparation using emulsion w/o/w technique. A disk was added to each siliconized microvial containing 1 ml of phosphate buffered saline (PBS) with 10% fetal bovine serum (FBS). Results show that embedding the microsphere in a porous PPF scaffold can eliminate the burst release of rhBMP-2.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages512
Number of pages1
StatePublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

Fingerprint

Scaffolds (biology)
Microspheres
Polypropylenes
Scaffolds
Kinetics
Propylene
Emulsions
Bone
Phosphates
Molecular weight
Proteins

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Jabbari, E., Florschutz, A. V., Pedersen, L. G., Liu, N., Lu, L., Currier, B. L., & Yaszemski, M. J. (2004). Release kinetics of rhBMP-2 from PLGA microspheres embedded in a porous poly (propylene fumarate) scaffold. In Transactions - 7th World Biomaterials Congress (pp. 512)

Release kinetics of rhBMP-2 from PLGA microspheres embedded in a porous poly (propylene fumarate) scaffold. / Jabbari, E.; Florschutz, A. V.; Pedersen, L. G.; Liu, N.; Lu, Lichun; Currier, B. L.; Yaszemski, Michael J.

Transactions - 7th World Biomaterials Congress. 2004. p. 512.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jabbari, E, Florschutz, AV, Pedersen, LG, Liu, N, Lu, L, Currier, BL & Yaszemski, MJ 2004, Release kinetics of rhBMP-2 from PLGA microspheres embedded in a porous poly (propylene fumarate) scaffold. in Transactions - 7th World Biomaterials Congress. pp. 512, Transactions - 7th World Biomaterials Congress, Sydney, Australia, 5/17/04.
Jabbari E, Florschutz AV, Pedersen LG, Liu N, Lu L, Currier BL et al. Release kinetics of rhBMP-2 from PLGA microspheres embedded in a porous poly (propylene fumarate) scaffold. In Transactions - 7th World Biomaterials Congress. 2004. p. 512
Jabbari, E. ; Florschutz, A. V. ; Pedersen, L. G. ; Liu, N. ; Lu, Lichun ; Currier, B. L. ; Yaszemski, Michael J. / Release kinetics of rhBMP-2 from PLGA microspheres embedded in a porous poly (propylene fumarate) scaffold. Transactions - 7th World Biomaterials Congress. 2004. pp. 512
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