Release kinetics of rhBMP-2 from PLGA microspheres embedded in a porous poly (propylene fumarate) scaffold

E. Jabbari, A. V. Florschutz, L. G. Pedersen, N. Liu, L. Lu, B. L. Currier, M. J. Yaszemski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

The release characteristics of human recombinant bone morphogenetic protein-2 (rh-BMP-2) from PLGA microspheres embedded in a porous poly(propylene furamate) (PPF) scaffold was investigated. PLGA with lactide to glycolide ratio and weight average molecular weight of 25 or 60 kg/mol was used for microsphere preparation using emulsion w/o/w technique. A disk was added to each siliconized microvial containing 1 ml of phosphate buffered saline (PBS) with 10% fetal bovine serum (FBS). Results show that embedding the microsphere in a porous PPF scaffold can eliminate the burst release of rhBMP-2.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

ASJC Scopus subject areas

  • Engineering(all)

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    Jabbari, E., Florschutz, A. V., Pedersen, L. G., Liu, N., Lu, L., Currier, B. L., & Yaszemski, M. J. (2004). Release kinetics of rhBMP-2 from PLGA microspheres embedded in a porous poly (propylene fumarate) scaffold. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).