Release kinetics of rhBMP-2 from PLGA microspheres embedded in a porous poly (propylene fumarate) scaffold

E. Jabbari; A. V. Florschutz; L. G. Pedersen; N. Liu; L. Lu; B. L. Currier; M. J. Yaszemski

Release kinetics of rhBMP-2 from PLGA microspheres embedded in a porous poly (propylene fumarate) scaffold

E. Jabbari, A. V. Florschutz, L. G. Pedersen, N. Liu, L. Lu, B. L. Currier, M. J. Yaszemski

Orthopedic Surgery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Scopus citations

Abstract

The release characteristics of human recombinant bone morphogenetic protein-2 (rh-BMP-2) from PLGA microspheres embedded in a porous poly(propylene furamate) (PPF) scaffold was investigated. PLGA with lactide to glycolide ratio and weight average molecular weight of 25 or 60 kg/mol was used for microsphere preparation using emulsion w/o/w technique. A disk was added to each siliconized microvial containing 1 ml of phosphate buffered saline (PBS) with 10% fetal bovine serum (FBS). Results show that embedding the microsphere in a porous PPF scaffold can eliminate the burst release of rhBMP-2.

Original language	English (US)
Title of host publication	Transactions - 7th World Biomaterials Congress
Pages	512
Number of pages	1
State	Published - 2004
Event	Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: May 17 2004 → May 21 2004

Publication series

Name	Transactions - 7th World Biomaterials Congress

Other

Other	Transactions - 7th World Biomaterials Congress
Country/Territory	Australia
City	Sydney
Period	5/17/04 → 5/21/04

ASJC Scopus subject areas

General Engineering

Cite this

Jabbari, E, Florschutz, AV, Pedersen, LG, Liu, N, Lu, L, Currier, BL & Yaszemski, MJ 2004, Release kinetics of rhBMP-2 from PLGA microspheres embedded in a porous poly (propylene fumarate) scaffold. in Transactions - 7th World Biomaterials Congress. Transactions - 7th World Biomaterials Congress, pp. 512, Transactions - 7th World Biomaterials Congress, Sydney, Australia, 5/17/04.

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abstract = "The release characteristics of human recombinant bone morphogenetic protein-2 (rh-BMP-2) from PLGA microspheres embedded in a porous poly(propylene furamate) (PPF) scaffold was investigated. PLGA with lactide to glycolide ratio and weight average molecular weight of 25 or 60 kg/mol was used for microsphere preparation using emulsion w/o/w technique. A disk was added to each siliconized microvial containing 1 ml of phosphate buffered saline (PBS) with 10% fetal bovine serum (FBS). Results show that embedding the microsphere in a porous PPF scaffold can eliminate the burst release of rhBMP-2.",

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AU - Jabbari, E.

AU - Florschutz, A. V.

AU - Pedersen, L. G.

AU - Liu, N.

AU - Lu, L.

AU - Currier, B. L.

AU - Yaszemski, M. J.

PY - 2004

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N2 - The release characteristics of human recombinant bone morphogenetic protein-2 (rh-BMP-2) from PLGA microspheres embedded in a porous poly(propylene furamate) (PPF) scaffold was investigated. PLGA with lactide to glycolide ratio and weight average molecular weight of 25 or 60 kg/mol was used for microsphere preparation using emulsion w/o/w technique. A disk was added to each siliconized microvial containing 1 ml of phosphate buffered saline (PBS) with 10% fetal bovine serum (FBS). Results show that embedding the microsphere in a porous PPF scaffold can eliminate the burst release of rhBMP-2.

AB - The release characteristics of human recombinant bone morphogenetic protein-2 (rh-BMP-2) from PLGA microspheres embedded in a porous poly(propylene furamate) (PPF) scaffold was investigated. PLGA with lactide to glycolide ratio and weight average molecular weight of 25 or 60 kg/mol was used for microsphere preparation using emulsion w/o/w technique. A disk was added to each siliconized microvial containing 1 ml of phosphate buffered saline (PBS) with 10% fetal bovine serum (FBS). Results show that embedding the microsphere in a porous PPF scaffold can eliminate the burst release of rhBMP-2.

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M3 - Conference contribution

AN - SCOPUS:13844280479

SN - 1877040193

SN - 9781877040191

T3 - Transactions - 7th World Biomaterials Congress

SP - 512

BT - Transactions - 7th World Biomaterials Congress

T2 - Transactions - 7th World Biomaterials Congress

Y2 - 17 May 2004 through 21 May 2004

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Release kinetics of rhBMP-2 from PLGA microspheres embedded in a porous poly (propylene fumarate) scaffold

Abstract

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