Relative contribution of neurotransmission failure to diaphragm fatigue

J. H. Kuei, R. Shadmehr, Gary C Sieck

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Two procedures were used to estimate the relative contribution of neurotransmission failure (NF3) to fatigue of the rat diaphragm at different rates of phrenic nerve stimulation. In one, direct muscle stimulation was intermittently superimposed on neural stimulation of the diaphragm, and the relative contribution of NF was estimated by the difference in generated tension. In a second procedure, diaphragm fatigue was induced by using either direct muscle stimulation (with complete blockade of the neuromuscular junction by d-tubocurare) or phrenic nerve stimulation. The relative contribution of NF to diaphragm fatigue was then estimated by comparing the force loss during these two modes of stimulation. With both procedures, it was observed that 1) the relative contribution of NF to diaphragm fatigue was <45% at each frequency of phrenic nerve stimulation; 2) the relative contribution of NF to diaphragm fatigue increased at higher rates of phrenic stimulation, reaching a maximum at 75 pulses/s; and 3) the relative contribution of NF to diaphragm fatigue reached a plateau after 2 min of repetitive stimulation.

Original languageEnglish (US)
Pages (from-to)174-180
Number of pages7
JournalJournal of Applied Physiology
Volume68
Issue number1
StatePublished - 1990
Externally publishedYes

Fingerprint

Diaphragm
Synaptic Transmission
Fatigue
Phrenic Nerve
Tubocurarine
Muscles
Neuromuscular Junction

Keywords

  • muscle
  • phrenic nerve
  • tension

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Kuei, J. H., Shadmehr, R., & Sieck, G. C. (1990). Relative contribution of neurotransmission failure to diaphragm fatigue. Journal of Applied Physiology, 68(1), 174-180.

Relative contribution of neurotransmission failure to diaphragm fatigue. / Kuei, J. H.; Shadmehr, R.; Sieck, Gary C.

In: Journal of Applied Physiology, Vol. 68, No. 1, 1990, p. 174-180.

Research output: Contribution to journalArticle

Kuei, JH, Shadmehr, R & Sieck, GC 1990, 'Relative contribution of neurotransmission failure to diaphragm fatigue', Journal of Applied Physiology, vol. 68, no. 1, pp. 174-180.
Kuei, J. H. ; Shadmehr, R. ; Sieck, Gary C. / Relative contribution of neurotransmission failure to diaphragm fatigue. In: Journal of Applied Physiology. 1990 ; Vol. 68, No. 1. pp. 174-180.
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