TY - JOUR
T1 - Relationships between thyroid hormone and antidepressant responses to total sleep deprivation in mood disorder patients
AU - Parekh, Priti I.
AU - Ketter, Terence A.
AU - Altshuler, Lori
AU - Frye, Mark A.
AU - Callahan, Ann
AU - Marangell, Lauren
AU - Post, Robert M.
PY - 1998/3/1
Y1 - 1998/3/1
N2 - Background: Acute transient antidepressant effects of sleep deprivation are consistently observed in 50% of depressed patients, but the mechanisms of these, at times, dramatic improvements in mood have not been adequately elucidated. Some, but not all, studies suggest a relationship to increased thyroid-stimulating hormone (TSH) secretion. Methods: TSH and other thyroid indices were measured at 8:00 AM after a baseline night's sleep and at 8:00 AM following a night of total sleep deprivation (S.D.) in 34 medication- free, affective disorder patients assessed with Hamilton, Beck, and Bunney- Hamburg depression ratings as well as two hourly self-ratings on a visual analog scale. Results: Compared with baseline, S.D. induced highly significant increases in TSH, levothyroxine, free levothyroxine, and triiodothyronine. The 12 S.D. responders tended to have greater TSH increases than the 15 nonresponders (p<.10). The change in Beck depression ratings significantly correlated with the change in TSH (r = -.40, p = .0496, n =24). Conclusions: These data are consistent with several other reports of a significant relationship between degree of antidepressant response to S.D. and increases in TSH measured at 8:00 AM near their usual nadir. Acute removal of the sleep-related break on the hypothalamic-pituitary-thyroid axis remains a promising candidate for the mechanism of sleep deprivation-induced improvement in mood in depressed patients.
AB - Background: Acute transient antidepressant effects of sleep deprivation are consistently observed in 50% of depressed patients, but the mechanisms of these, at times, dramatic improvements in mood have not been adequately elucidated. Some, but not all, studies suggest a relationship to increased thyroid-stimulating hormone (TSH) secretion. Methods: TSH and other thyroid indices were measured at 8:00 AM after a baseline night's sleep and at 8:00 AM following a night of total sleep deprivation (S.D.) in 34 medication- free, affective disorder patients assessed with Hamilton, Beck, and Bunney- Hamburg depression ratings as well as two hourly self-ratings on a visual analog scale. Results: Compared with baseline, S.D. induced highly significant increases in TSH, levothyroxine, free levothyroxine, and triiodothyronine. The 12 S.D. responders tended to have greater TSH increases than the 15 nonresponders (p<.10). The change in Beck depression ratings significantly correlated with the change in TSH (r = -.40, p = .0496, n =24). Conclusions: These data are consistent with several other reports of a significant relationship between degree of antidepressant response to S.D. and increases in TSH measured at 8:00 AM near their usual nadir. Acute removal of the sleep-related break on the hypothalamic-pituitary-thyroid axis remains a promising candidate for the mechanism of sleep deprivation-induced improvement in mood in depressed patients.
KW - Affective disorders
KW - Depression
KW - Sleep deprivation
KW - Thyroid hormones
KW - thyroid-stimulating hormone
UR - http://www.scopus.com/inward/record.url?scp=0032032883&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032032883&partnerID=8YFLogxK
U2 - 10.1016/S0006-3223(97)00513-1
DO - 10.1016/S0006-3223(97)00513-1
M3 - Article
C2 - 9513756
AN - SCOPUS:0032032883
SN - 0006-3223
VL - 43
SP - 392
EP - 394
JO - Biological psychiatry
JF - Biological psychiatry
IS - 5
ER -