Background: The aim of the present study was to explore the association between Parkinson's disease (PD) clinical characteristics and cardiac autonomic control across sleep stages. Methods: Frequency-domain heart rate variability (HRV) measures were estimated in 18 PD patients undergoing a night of polysomnography. Results: Significant relationships were found between PD severity and nocturnal HRV indices. The associations were restricted to rapid eye movement (R) sleep. Conclusions: The progressive nocturnal cardiac autonomic impairment occurring with more severe PD can be subclinical emerging only during conditions requiring active modulation of physiological functions such as R-sleep.
- Heart rate variability
- Parkinson's disease
ASJC Scopus subject areas
- Endocrine and Autonomic Systems
- Clinical Neurology
- Cellular and Molecular Neuroscience