Relationship between seizure frequency and functional abnormalities in limbic network of medial temporal lobe epilepsy

Hang Joon Jo, Daniel L. Kenney-Jung, Irena Balzekas, Kirk M. Welker, David T. Jones, Paul E. Croarkin, Eduardo E. Benarroch, Gregory A. Worrell

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: We compared resting-state functional connectivity (RSFC) among limbic and temporal lobe regions between patients with medial temporal lobe epilepsy (mTLE) and healthy control subjects to identify imaging evidence of functional networks related to seizure frequency, age of seizure onset, and duration of epilepsy. Methods: Twelve patients with drug-resistant, unilateral medial temporal lobe epilepsy and 12 healthy control subjects matched for age, sex, and handedness participated in the imaging experiments. We used network-based statistics to compare functional connectivity graphs in patients with mTLE and healthy controls to investigate the relationship between functional connectivity abnormalities and seizure frequency. Results: Among mTLE patients, we found functional network abnormalities throughout the limbic system, but primarily in the hemisphere ipsilateral to the seizure focus. The RSFCs between ipsilateral hypothalamus and ventral anterior cingulate cortex and between ipsilateral subiculum and contralateral posterior cingulate cortex were highly correlated with seizure frequency. Discussion: These findings suggest that in mTLE, changes in limbic networks ipsilateral to the epileptic focus are common. The pathological changes in connectivity between cingulate cortex, hypothalamus and subiculum ipsilateral to the seizure focus were correlated with increased seizure frequency.

Original languageEnglish (US)
Article number488
JournalFrontiers in Neurology
Volume10
Issue numberMAY
DOIs
StatePublished - Jan 1 2019

Fingerprint

Temporal Lobe Epilepsy
Seizures
Gyrus Cinguli
Temporal Lobe
Hypothalamus
Hippocampus
Healthy Volunteers
Limbic System
Functional Laterality
Age of Onset
Epilepsy
Pharmaceutical Preparations

Keywords

  • Functional magnetic resonance imaging
  • Limbic system
  • Medial temporal lobe epilepsy
  • Network-based statistics
  • Partial seizure

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Relationship between seizure frequency and functional abnormalities in limbic network of medial temporal lobe epilepsy. / Jo, Hang Joon; Kenney-Jung, Daniel L.; Balzekas, Irena; Welker, Kirk M.; Jones, David T.; Croarkin, Paul E.; Benarroch, Eduardo E.; Worrell, Gregory A.

In: Frontiers in Neurology, Vol. 10, No. MAY, 488, 01.01.2019.

Research output: Contribution to journalArticle

@article{4c01ba5a5891444ea6a4eda58ffa5a2e,
title = "Relationship between seizure frequency and functional abnormalities in limbic network of medial temporal lobe epilepsy",
abstract = "Background: We compared resting-state functional connectivity (RSFC) among limbic and temporal lobe regions between patients with medial temporal lobe epilepsy (mTLE) and healthy control subjects to identify imaging evidence of functional networks related to seizure frequency, age of seizure onset, and duration of epilepsy. Methods: Twelve patients with drug-resistant, unilateral medial temporal lobe epilepsy and 12 healthy control subjects matched for age, sex, and handedness participated in the imaging experiments. We used network-based statistics to compare functional connectivity graphs in patients with mTLE and healthy controls to investigate the relationship between functional connectivity abnormalities and seizure frequency. Results: Among mTLE patients, we found functional network abnormalities throughout the limbic system, but primarily in the hemisphere ipsilateral to the seizure focus. The RSFCs between ipsilateral hypothalamus and ventral anterior cingulate cortex and between ipsilateral subiculum and contralateral posterior cingulate cortex were highly correlated with seizure frequency. Discussion: These findings suggest that in mTLE, changes in limbic networks ipsilateral to the epileptic focus are common. The pathological changes in connectivity between cingulate cortex, hypothalamus and subiculum ipsilateral to the seizure focus were correlated with increased seizure frequency.",
keywords = "Functional magnetic resonance imaging, Limbic system, Medial temporal lobe epilepsy, Network-based statistics, Partial seizure",
author = "Jo, {Hang Joon} and Kenney-Jung, {Daniel L.} and Irena Balzekas and Welker, {Kirk M.} and Jones, {David T.} and Croarkin, {Paul E.} and Benarroch, {Eduardo E.} and Worrell, {Gregory A.}",
year = "2019",
month = "1",
day = "1",
doi = "10.3389/fneur.2019.00488",
language = "English (US)",
volume = "10",
journal = "Frontiers in Neurology",
issn = "1664-2295",
publisher = "Frontiers Research Foundation",
number = "MAY",

}

TY - JOUR

T1 - Relationship between seizure frequency and functional abnormalities in limbic network of medial temporal lobe epilepsy

AU - Jo, Hang Joon

AU - Kenney-Jung, Daniel L.

AU - Balzekas, Irena

AU - Welker, Kirk M.

AU - Jones, David T.

AU - Croarkin, Paul E.

AU - Benarroch, Eduardo E.

AU - Worrell, Gregory A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: We compared resting-state functional connectivity (RSFC) among limbic and temporal lobe regions between patients with medial temporal lobe epilepsy (mTLE) and healthy control subjects to identify imaging evidence of functional networks related to seizure frequency, age of seizure onset, and duration of epilepsy. Methods: Twelve patients with drug-resistant, unilateral medial temporal lobe epilepsy and 12 healthy control subjects matched for age, sex, and handedness participated in the imaging experiments. We used network-based statistics to compare functional connectivity graphs in patients with mTLE and healthy controls to investigate the relationship between functional connectivity abnormalities and seizure frequency. Results: Among mTLE patients, we found functional network abnormalities throughout the limbic system, but primarily in the hemisphere ipsilateral to the seizure focus. The RSFCs between ipsilateral hypothalamus and ventral anterior cingulate cortex and between ipsilateral subiculum and contralateral posterior cingulate cortex were highly correlated with seizure frequency. Discussion: These findings suggest that in mTLE, changes in limbic networks ipsilateral to the epileptic focus are common. The pathological changes in connectivity between cingulate cortex, hypothalamus and subiculum ipsilateral to the seizure focus were correlated with increased seizure frequency.

AB - Background: We compared resting-state functional connectivity (RSFC) among limbic and temporal lobe regions between patients with medial temporal lobe epilepsy (mTLE) and healthy control subjects to identify imaging evidence of functional networks related to seizure frequency, age of seizure onset, and duration of epilepsy. Methods: Twelve patients with drug-resistant, unilateral medial temporal lobe epilepsy and 12 healthy control subjects matched for age, sex, and handedness participated in the imaging experiments. We used network-based statistics to compare functional connectivity graphs in patients with mTLE and healthy controls to investigate the relationship between functional connectivity abnormalities and seizure frequency. Results: Among mTLE patients, we found functional network abnormalities throughout the limbic system, but primarily in the hemisphere ipsilateral to the seizure focus. The RSFCs between ipsilateral hypothalamus and ventral anterior cingulate cortex and between ipsilateral subiculum and contralateral posterior cingulate cortex were highly correlated with seizure frequency. Discussion: These findings suggest that in mTLE, changes in limbic networks ipsilateral to the epileptic focus are common. The pathological changes in connectivity between cingulate cortex, hypothalamus and subiculum ipsilateral to the seizure focus were correlated with increased seizure frequency.

KW - Functional magnetic resonance imaging

KW - Limbic system

KW - Medial temporal lobe epilepsy

KW - Network-based statistics

KW - Partial seizure

UR - http://www.scopus.com/inward/record.url?scp=85068085219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068085219&partnerID=8YFLogxK

U2 - 10.3389/fneur.2019.00488

DO - 10.3389/fneur.2019.00488

M3 - Article

AN - SCOPUS:85068085219

VL - 10

JO - Frontiers in Neurology

JF - Frontiers in Neurology

SN - 1664-2295

IS - MAY

M1 - 488

ER -