Relationship between hepatitis C genotype and severity of recurrent hepatitis C after liver transplantation

Fredric D. Gordon, John J. Poterucha, Jeff Germer, Nizar N. Zein, Kenneth P. Batts, John B. Gross, Russell Wiesner, David Persing

Research output: Contribution to journalArticle

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Abstract

Background. Recurrence of hepatitis C virus (HCV) infection after liver transplantation is universal, but the relationship between hepatitis C genotype and posttransplant outcome has been controversial. The aim of this study was to assess the relationship between hepatitis C genotype on posttransplant frequency of recurrent hepatitis, histologic severity of recurrence, and progression to cirrhosis. Methods. We studied 42 HCV RNA positive patients who received transplants between 1985 and 1994. Sera were tested for HCV RNA and protocol liver biopsies were in obtained the posttransplant period. Biopsies were scored according to the histologic activity index (HAI) and staged in a blinded fashion. Results. The distribution of hepatitis C genotypes distribution was as follows: 1a, 19 (45%); 1b, 17 (40%); 2b, 3 (7%); and 1 each of 2a, 3a, and 4a. There was histologic evidence of hepatitis in 38 of 42 (90.4%) of patients. Hepatitis C was mild, moderate, or severe (HAI>3) in 38% of grafts and minimal (HAI 0-3) in 62%. Overall HAI scores and histologic stage were higher in the genotype 1b group. Six of 17 (35%) genotype 1b patients had cirrhosis compared with 2 of 25 (8%) in the non-1b genotype group. Conclusions. (1) Histologic evidence of recurrent hepatitis C is seen in 90% of liver allografts; (2) Histologic hepatitis C recurs with similar frequency in genotype 1b and non-1b recipients; (3) Genotype 1b is associated with more severe histologic disease recurrence than non-1b genotypes; (4) Genotype 1b appears to be associated with a higher degree of posttransplant fibrosis and cirrhosis than non-1b genotypes.

Original languageEnglish (US)
Pages (from-to)1419-1423
Number of pages5
JournalTransplantation
Volume63
Issue number10
DOIs
StatePublished - May 27 1997

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Hepatitis C
Liver Transplantation
Genotype
Fibrosis
Hepacivirus
Recurrence
Hepatitis
RNA
Transplants
Biopsy
Liver
Virus Diseases
Allografts

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Gordon, F. D., Poterucha, J. J., Germer, J., Zein, N. N., Batts, K. P., Gross, J. B., ... Persing, D. (1997). Relationship between hepatitis C genotype and severity of recurrent hepatitis C after liver transplantation. Transplantation, 63(10), 1419-1423. https://doi.org/10.1097/00007890-199705270-00009

Relationship between hepatitis C genotype and severity of recurrent hepatitis C after liver transplantation. / Gordon, Fredric D.; Poterucha, John J.; Germer, Jeff; Zein, Nizar N.; Batts, Kenneth P.; Gross, John B.; Wiesner, Russell; Persing, David.

In: Transplantation, Vol. 63, No. 10, 27.05.1997, p. 1419-1423.

Research output: Contribution to journalArticle

Gordon, FD, Poterucha, JJ, Germer, J, Zein, NN, Batts, KP, Gross, JB, Wiesner, R & Persing, D 1997, 'Relationship between hepatitis C genotype and severity of recurrent hepatitis C after liver transplantation', Transplantation, vol. 63, no. 10, pp. 1419-1423. https://doi.org/10.1097/00007890-199705270-00009
Gordon, Fredric D. ; Poterucha, John J. ; Germer, Jeff ; Zein, Nizar N. ; Batts, Kenneth P. ; Gross, John B. ; Wiesner, Russell ; Persing, David. / Relationship between hepatitis C genotype and severity of recurrent hepatitis C after liver transplantation. In: Transplantation. 1997 ; Vol. 63, No. 10. pp. 1419-1423.
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abstract = "Background. Recurrence of hepatitis C virus (HCV) infection after liver transplantation is universal, but the relationship between hepatitis C genotype and posttransplant outcome has been controversial. The aim of this study was to assess the relationship between hepatitis C genotype on posttransplant frequency of recurrent hepatitis, histologic severity of recurrence, and progression to cirrhosis. Methods. We studied 42 HCV RNA positive patients who received transplants between 1985 and 1994. Sera were tested for HCV RNA and protocol liver biopsies were in obtained the posttransplant period. Biopsies were scored according to the histologic activity index (HAI) and staged in a blinded fashion. Results. The distribution of hepatitis C genotypes distribution was as follows: 1a, 19 (45{\%}); 1b, 17 (40{\%}); 2b, 3 (7{\%}); and 1 each of 2a, 3a, and 4a. There was histologic evidence of hepatitis in 38 of 42 (90.4{\%}) of patients. Hepatitis C was mild, moderate, or severe (HAI>3) in 38{\%} of grafts and minimal (HAI 0-3) in 62{\%}. Overall HAI scores and histologic stage were higher in the genotype 1b group. Six of 17 (35{\%}) genotype 1b patients had cirrhosis compared with 2 of 25 (8{\%}) in the non-1b genotype group. Conclusions. (1) Histologic evidence of recurrent hepatitis C is seen in 90{\%} of liver allografts; (2) Histologic hepatitis C recurs with similar frequency in genotype 1b and non-1b recipients; (3) Genotype 1b is associated with more severe histologic disease recurrence than non-1b genotypes; (4) Genotype 1b appears to be associated with a higher degree of posttransplant fibrosis and cirrhosis than non-1b genotypes.",
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T1 - Relationship between hepatitis C genotype and severity of recurrent hepatitis C after liver transplantation

AU - Gordon, Fredric D.

AU - Poterucha, John J.

AU - Germer, Jeff

AU - Zein, Nizar N.

AU - Batts, Kenneth P.

AU - Gross, John B.

AU - Wiesner, Russell

AU - Persing, David

PY - 1997/5/27

Y1 - 1997/5/27

N2 - Background. Recurrence of hepatitis C virus (HCV) infection after liver transplantation is universal, but the relationship between hepatitis C genotype and posttransplant outcome has been controversial. The aim of this study was to assess the relationship between hepatitis C genotype on posttransplant frequency of recurrent hepatitis, histologic severity of recurrence, and progression to cirrhosis. Methods. We studied 42 HCV RNA positive patients who received transplants between 1985 and 1994. Sera were tested for HCV RNA and protocol liver biopsies were in obtained the posttransplant period. Biopsies were scored according to the histologic activity index (HAI) and staged in a blinded fashion. Results. The distribution of hepatitis C genotypes distribution was as follows: 1a, 19 (45%); 1b, 17 (40%); 2b, 3 (7%); and 1 each of 2a, 3a, and 4a. There was histologic evidence of hepatitis in 38 of 42 (90.4%) of patients. Hepatitis C was mild, moderate, or severe (HAI>3) in 38% of grafts and minimal (HAI 0-3) in 62%. Overall HAI scores and histologic stage were higher in the genotype 1b group. Six of 17 (35%) genotype 1b patients had cirrhosis compared with 2 of 25 (8%) in the non-1b genotype group. Conclusions. (1) Histologic evidence of recurrent hepatitis C is seen in 90% of liver allografts; (2) Histologic hepatitis C recurs with similar frequency in genotype 1b and non-1b recipients; (3) Genotype 1b is associated with more severe histologic disease recurrence than non-1b genotypes; (4) Genotype 1b appears to be associated with a higher degree of posttransplant fibrosis and cirrhosis than non-1b genotypes.

AB - Background. Recurrence of hepatitis C virus (HCV) infection after liver transplantation is universal, but the relationship between hepatitis C genotype and posttransplant outcome has been controversial. The aim of this study was to assess the relationship between hepatitis C genotype on posttransplant frequency of recurrent hepatitis, histologic severity of recurrence, and progression to cirrhosis. Methods. We studied 42 HCV RNA positive patients who received transplants between 1985 and 1994. Sera were tested for HCV RNA and protocol liver biopsies were in obtained the posttransplant period. Biopsies were scored according to the histologic activity index (HAI) and staged in a blinded fashion. Results. The distribution of hepatitis C genotypes distribution was as follows: 1a, 19 (45%); 1b, 17 (40%); 2b, 3 (7%); and 1 each of 2a, 3a, and 4a. There was histologic evidence of hepatitis in 38 of 42 (90.4%) of patients. Hepatitis C was mild, moderate, or severe (HAI>3) in 38% of grafts and minimal (HAI 0-3) in 62%. Overall HAI scores and histologic stage were higher in the genotype 1b group. Six of 17 (35%) genotype 1b patients had cirrhosis compared with 2 of 25 (8%) in the non-1b genotype group. Conclusions. (1) Histologic evidence of recurrent hepatitis C is seen in 90% of liver allografts; (2) Histologic hepatitis C recurs with similar frequency in genotype 1b and non-1b recipients; (3) Genotype 1b is associated with more severe histologic disease recurrence than non-1b genotypes; (4) Genotype 1b appears to be associated with a higher degree of posttransplant fibrosis and cirrhosis than non-1b genotypes.

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