Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients

Gen Shinozaki, Sheila Jowsey, Hatem Amer, Joanna M Biernacka, Colin Colby, Denise Walker, John Black, James Rundell, Mark D Stegall, David A. Mrazek

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Several polymorphisms in FK506 Binding Protein gene (FKBP5) and a history of child abuse have been shown to be associated with an increased risk for posttraumatic stress disorder (PTSD). It has also been demonstrated that the same polymorphisms of FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. However, there are only limited numbers of studies replicating the polymorphisms as vulnerability factors for the development of mental illnesses, such as PTSD and depression after stressful life event, especially with a specific incidence, such as kidney transplant surgery. Methods: A retrospective analysis was conducted using the electronic medical records of 131 adult kidney transplant recipients. Depression severity after kidney transplantation was measured by PHQ-9, and stored blood was genotyped for variants in the Serotonin Transporter (SLC6A4), Brain-Derived Neurotrophic Factor, Catecholamine-O-Methyltransferase, Corticotropin-Releasing Hormone Receptor, and FKBP5 genes. Spearman correlations were used to test for association between genetic variants and depression severity. Results: The rare alleles at three out of four SNPs in FKBP5 (rs1360780, rs9296158, and rs9470080) were associated with increased PHQ-9 scores (P<.05), whereas the last FKBP5 SNP (rs3800373) showed a trend of association (P<.10). All four FKBP5 SNPs are in strong linkage disequilibrium. Although in a subgroup of Caucasian non-Hispanic subjects the association was not statistically significant, the direction of association was consistent with that observed in the entire sample as well as in previous studies. Polymorphisms in genes other than FKBP5 were not associated with PHQ-9 scores. Conclusions: Polymorphisms in FKBP5 may be associated with higher depression scores in kidney transplant recipients.

Original languageEnglish (US)
Pages (from-to)1111-1118
Number of pages8
JournalDepression and Anxiety
Volume28
Issue number12
DOIs
StatePublished - Dec 21 2011

Fingerprint

Depression
Single Nucleotide Polymorphism
Kidney
Post-Traumatic Stress Disorders
Tacrolimus Binding Proteins
Genes
Corticotropin-Releasing Hormone Receptors
Serotonin Plasma Membrane Transport Proteins
Electronic Health Records
Child Abuse
Brain-Derived Neurotrophic Factor
Linkage Disequilibrium
Methyltransferases
Kidney Transplantation
Antidepressive Agents
Catecholamines
Alleles
Transplants
Recurrence
Transplant Recipients

Keywords

  • depression
  • FKBP5
  • kidney transplant
  • stress
  • vulnerability

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients. / Shinozaki, Gen; Jowsey, Sheila; Amer, Hatem; Biernacka, Joanna M; Colby, Colin; Walker, Denise; Black, John; Rundell, James; Stegall, Mark D; Mrazek, David A.

In: Depression and Anxiety, Vol. 28, No. 12, 21.12.2011, p. 1111-1118.

Research output: Contribution to journalArticle

Shinozaki, G, Jowsey, S, Amer, H, Biernacka, JM, Colby, C, Walker, D, Black, J, Rundell, J, Stegall, MD & Mrazek, DA 2011, 'Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients', Depression and Anxiety, vol. 28, no. 12, pp. 1111-1118. https://doi.org/10.1002/da.20879
Shinozaki, Gen ; Jowsey, Sheila ; Amer, Hatem ; Biernacka, Joanna M ; Colby, Colin ; Walker, Denise ; Black, John ; Rundell, James ; Stegall, Mark D ; Mrazek, David A. / Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients. In: Depression and Anxiety. 2011 ; Vol. 28, No. 12. pp. 1111-1118.
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AU - Amer, Hatem

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AU - Colby, Colin

AU - Walker, Denise

AU - Black, John

AU - Rundell, James

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