Regulatory role of prostanoids in glomerular microcirculation of remnant nephrons

Karl A Nath, D. H. Chmielewski, T. H. Hostetter

Research output: Chapter in Book/Report/Conference proceedingChapter

44 Citations (Scopus)

Abstract

The glomerular microcirculation of the remnant nephron is characterized by reduced afferent (R(A)) and efferent (R(E)) arteriolar resistances and markedly increased single nephron glomerular plasma flow and filtration rates. We investigated the role of prostanoid production in mediating these adaptive alterations in glomerular hemodynamics after the reduction of renal mass. Acute administration of indomethacin, 5 mg/kg iv in anesthetized euvolemic, Sprague-Dawley rats with intact kidneys led to no significant alteration in renal hemodynamics, whereas in similarly prepared subtotally nephrectomized rats such inhibition significantly reduced remnant kidney glomerular filtration rate from 0.57 ± 0.07 to 0.45 ± 0.05 ml/min and single nephron glomerular filtration rate (SNGFR) from 93 ± 4 to 72 ± 5 nl/min. This reduction of SNGFR was due to diminutions in the glomerular ultrafiltration coefficient (K(f)) from basal values of 0.061 ± 0.004 to 0.050 ± 0.004 nl·s-1·mmHg-1 and in initial glomerular capillary plasma flow rate (Q̇(A)) from 416 ± 42 to 321 ± 42 nl/min. The decrease in Q̇(A) was a consequence of proportional increases in R(A) and R(E). In other groups of animals we demonstrated that urinary excretions of both vasodilatory as well as vasoconstrictor prostanoids per surviving nephron increase several fold in subtotally nephrectomized rats compared with rats with intact kidneys and that administration of indomethacin, 5 mg/kg iv, reduced urinary excretions of both vasodilatory prostaglandins, prostaglandin E and 6-keto-prostaglandin F(1α), as well as vasoconstrictor prostanoid, thromboxane B2, to the same degrees in both subtotally nephrectomized rats and rats with intact kidneys. We conclude that after the reduction of renal mass adaptive increments in synthesis of both vasodilatory and vasoconstrictor prostanoids occur in surviving nephrons. The hemodynamic effects of prostaglandins on R(A) and R(E) and on K(f) account, at least in part, for the increments in single nephron glomerular plasma flow and filtration rates.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume252
Edition5
StatePublished - 1987
Externally publishedYes

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Nephrons
Microcirculation
Prostaglandins
Kidney
Vasoconstrictor Agents
Glomerular Filtration Rate
Hemodynamics
Indomethacin
Thromboxane B2
Ultrafiltration
Prostaglandins F
Prostaglandins E
Sprague Dawley Rats

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nath, K. A., Chmielewski, D. H., & Hostetter, T. H. (1987). Regulatory role of prostanoids in glomerular microcirculation of remnant nephrons. In American Journal of Physiology - Renal Fluid and Electrolyte Physiology (5 ed., Vol. 252)

Regulatory role of prostanoids in glomerular microcirculation of remnant nephrons. / Nath, Karl A; Chmielewski, D. H.; Hostetter, T. H.

American Journal of Physiology - Renal Fluid and Electrolyte Physiology. Vol. 252 5. ed. 1987.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nath, KA, Chmielewski, DH & Hostetter, TH 1987, Regulatory role of prostanoids in glomerular microcirculation of remnant nephrons. in American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 5 edn, vol. 252.
Nath KA, Chmielewski DH, Hostetter TH. Regulatory role of prostanoids in glomerular microcirculation of remnant nephrons. In American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 5 ed. Vol. 252. 1987
Nath, Karl A ; Chmielewski, D. H. ; Hostetter, T. H. / Regulatory role of prostanoids in glomerular microcirculation of remnant nephrons. American Journal of Physiology - Renal Fluid and Electrolyte Physiology. Vol. 252 5. ed. 1987.
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