TY - JOUR
T1 - Regulation of T-cell activation by the cytoskeleton
AU - Billadeau, Daniel D.
AU - Nolz, Jeffrey C.
AU - Gomez, Timothy S.
PY - 2007/2/1
Y1 - 2007/2/1
N2 - To become activated, T cells must efficiently recognize antigen-presenting cells or target cells through several complex cytoskeleton-dependent processes, including integrin-mediated adhesion, immunological-synapse formation, cellular polarization, receptor sequestration and signalling. The actin and microtubule systems provide the dynamic cellular framework that is required to orchestrate these processes and ultimately contol T-cell activation. Here, we discuss recent advances that have furthered our understanding of the crucial importance of the T-cell cytoskeleton in controlling these aspects of T-cell immune recognition.
AB - To become activated, T cells must efficiently recognize antigen-presenting cells or target cells through several complex cytoskeleton-dependent processes, including integrin-mediated adhesion, immunological-synapse formation, cellular polarization, receptor sequestration and signalling. The actin and microtubule systems provide the dynamic cellular framework that is required to orchestrate these processes and ultimately contol T-cell activation. Here, we discuss recent advances that have furthered our understanding of the crucial importance of the T-cell cytoskeleton in controlling these aspects of T-cell immune recognition.
UR - http://www.scopus.com/inward/record.url?scp=33846626054&partnerID=8YFLogxK
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U2 - 10.1038/nri2021
DO - 10.1038/nri2021
M3 - Review article
C2 - 17259969
AN - SCOPUS:33846626054
VL - 7
SP - 131
EP - 143
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
SN - 1474-1733
IS - 2
ER -