Regulation of Rho GTPases by p120-catenin

P. Z. Anastasiadis, A. B. Reynolds

Research output: Contribution to journalReview article

222 Scopus citations

Abstract

Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism of action and provide a potential explanation for the metastatic phenotype exhibited in carcinoma cells that have lost E cadherin expression.

Original languageEnglish (US)
Pages (from-to)604-610
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume13
Issue number5
DOIs
StatePublished - Oct 1 2001

ASJC Scopus subject areas

  • Cell Biology

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