Regulation of Rho GTPases by p120-catenin

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism of action and provide a potential explanation for the metastatic phenotype exhibited in carcinoma cells that have lost E cadherin expression.

Original languageEnglish (US)
Pages (from-to)604-610
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume13
Issue number5
DOIs
StatePublished - Oct 1 2001
Externally publishedYes

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rho GTP-Binding Proteins
Phenotype
Cadherins
Adhesives
Carcinoma
delta catenin

ASJC Scopus subject areas

  • Cell Biology

Cite this

Regulation of Rho GTPases by p120-catenin. / Anastasiadis, Panagiotis Z; Reynolds, A. B.

In: Current Opinion in Cell Biology, Vol. 13, No. 5, 01.10.2001, p. 604-610.

Research output: Contribution to journalArticle

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