Regulation of Rho GTPases by p120-catenin

P. Z. Anastasiadis; A. B. Reynolds

doi:10.1016/S0955-0674(00)00258-1

Regulation of Rho GTPases by p120-catenin

P. Z. Anastasiadis, A. B. Reynolds

Cancer Biology

Research output: Contribution to journal › Review article › peer-review

225 Scopus citations

Abstract

Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism of action and provide a potential explanation for the metastatic phenotype exhibited in carcinoma cells that have lost E cadherin expression.

Original language	English (US)
Pages (from-to)	604-610
Number of pages	7
Journal	Current Opinion in Cell Biology
Volume	13
Issue number	5
DOIs	https://doi.org/10.1016/S0955-0674(00)00258-1
State	Published - Oct 1 2001

ASJC Scopus subject areas

Cell Biology

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10.1016/S0955-0674(00)00258-1

Cite this

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title = "Regulation of Rho GTPases by p120-catenin",

abstract = "Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism of action and provide a potential explanation for the metastatic phenotype exhibited in carcinoma cells that have lost E cadherin expression.",

author = "Anastasiadis, {P. Z.} and Reynolds, {A. B.}",

note = "Funding Information: This work was supported by National Institutes of Health grant CA55724, and by the Vanderbilt Ingram Cancer Center, through the Cancer Center support grant CA69485. ",

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AU - Anastasiadis, P. Z.

AU - Reynolds, A. B.

N1 - Funding Information: This work was supported by National Institutes of Health grant CA55724, and by the Vanderbilt Ingram Cancer Center, through the Cancer Center support grant CA69485.

PY - 2001/10/1

Y1 - 2001/10/1

N2 - Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism of action and provide a potential explanation for the metastatic phenotype exhibited in carcinoma cells that have lost E cadherin expression.

AB - Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance between adhesive and motile cellular phenotypes. The observations in these reports provide important new clues toward p120's mechanism of action and provide a potential explanation for the metastatic phenotype exhibited in carcinoma cells that have lost E cadherin expression.

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Regulation of Rho GTPases by p120-catenin

Abstract

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