TY - JOUR
T1 - Regulation of forearm lipolysis in different types of obesity
T2 - In Vivo evidence for adipocyte heterogeneity
AU - Jensen, Michael D.
PY - 1991/1
Y1 - 1991/1
N2 - Forearm and systemic adipose tissue free fatty acid (FFA) release was measured in eight nonobese, six lower-body obese, and eight upper-body obese women under basal, hyperinsulinemic, and hypoinsulinemic conditions to determine whether forearm fat is regulated in a similar manner as whole body fat. Results: Adipose tissue palmitate release was greater from forearm than whole body (5.97±0.75 vs. 3.84±0.34 μmol·kg fat-1·min-1, respectively, P < 0.005, n = 22 subjects). Systemic palmitate release, relative to fat mass, was significantly (P < 0.01) greater in nonobese than upper-body obese, and upper-body obese than lower-body obese women, and forearm adipose tissue palmitate release followed the same pattern. Hyperinsulinemia suppressed systemic and forearm lipolysis to similar degrees, however, hypoinsulinemia consistently increased systemic palmitate flux without increasing forearm palmitate release. These results confirm the heterogeneity of adipose tissue in an in vivo model and emphasize the need to consider which adipose tissue depots are responsible for the differences in systemic FFA flux in obese and nonobese humans.
AB - Forearm and systemic adipose tissue free fatty acid (FFA) release was measured in eight nonobese, six lower-body obese, and eight upper-body obese women under basal, hyperinsulinemic, and hypoinsulinemic conditions to determine whether forearm fat is regulated in a similar manner as whole body fat. Results: Adipose tissue palmitate release was greater from forearm than whole body (5.97±0.75 vs. 3.84±0.34 μmol·kg fat-1·min-1, respectively, P < 0.005, n = 22 subjects). Systemic palmitate release, relative to fat mass, was significantly (P < 0.01) greater in nonobese than upper-body obese, and upper-body obese than lower-body obese women, and forearm adipose tissue palmitate release followed the same pattern. Hyperinsulinemia suppressed systemic and forearm lipolysis to similar degrees, however, hypoinsulinemia consistently increased systemic palmitate flux without increasing forearm palmitate release. These results confirm the heterogeneity of adipose tissue in an in vivo model and emphasize the need to consider which adipose tissue depots are responsible for the differences in systemic FFA flux in obese and nonobese humans.
KW - Body composition
KW - Body fat distribution
KW - Free fatty acids
KW - Insulin
KW - [1-C]palmitate
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U2 - 10.1172/JCI114969
DO - 10.1172/JCI114969
M3 - Article
C2 - 1985095
AN - SCOPUS:0026026254
SN - 0021-9738
VL - 87
SP - 187
EP - 193
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 1
ER -