Abstract
Background The incidence of all-location regional recurrence after sentinel lymph node biopsy is not well documented. This study attempts to identify risk factors. Methods A prospectively maintained database was queried to identify patients with a regional recurrence of breast cancer after a first operation for invasive unilateral breast cancer. Patients with regional recurrence were compared with those alive and disease free at 5 years. Results Twenty-one of 1,060 patients (2%) experienced a regional recurrence. Most patients (95%) underwent sentinel lymph node biopsy as their axillary staging. Those with regional recurrences had larger tumors (P <.001), higher stage disease (P <.001), more estrogen receptor- and triple-negative breast cancers (P <.001), and more positive lymph nodes (P =.007). Mastectomy (P =.001) and receipt of neoadjuvant and/or chemotherapy (P <.001) were more common among those with regional recurrences. Conclusions Regional recurrence of breast cancer occurs infrequently. Risk factors include high-risk cancers, higher stage at presentation, nodal involvement, and need for therapies reflecting higher risk biology.
Original language | English (US) |
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Pages (from-to) | 1155-1161 |
Number of pages | 7 |
Journal | American journal of surgery |
Volume | 210 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1 2015 |
Keywords
- Breast cancer
- Regional recurrence
- Sentinel lymph node biopsy
ASJC Scopus subject areas
- Surgery