TY - JOUR
T1 - Reduced fractional anisotropy of the genu of the corpus callosum as a cerebrovascular disease marker and predictor of longitudinal cognition in MCI
AU - Raghavan, Sheelakumari
AU - Przybelski, Scott A.
AU - Reid, Robert I.
AU - Graff-Radford, Jonathan
AU - Lesnick, Timothy G.
AU - Zuk, Samantha M.
AU - Knopman, David S.
AU - Machulda, Mary M.
AU - Mielke, Michelle M.
AU - Petersen, Ronald C.
AU - Jack, Clifford R.
AU - Vemuri, Prashanthi
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/12
Y1 - 2020/12
N2 - Our goal was to evaluate the utility of diffusion tensor imaging (DTI) for predicting future cognitive decline in mild cognitive impairment (MCI) in conjunction with Alzheimer's disease (AD) biomarkers (amyloid positron emission tomography and AD signature neurodegeneration) in 132 MCI individuals ≥60 year old with structural magnetic resonance imaging, DTI, amyloid positron emission tomography, and at least one clinical follow-up. We used mixed-effect models to evaluate the prognostic ability of fractional anisotropy of the genu of the corpus callosum (FA-Genu), as a cerebrovascular disease marker, for predicting cognitive decline along with AD biomarkers. We contrasted the value of white matter hyperintensities, a traditional cerebrovascular disease marker as well as FA in the hippocampal cingulum bundle with the FA-Genu models. FA-Genu significantly predicted cognitive decline even after accounting for AD biomarkers. WMH was not associated with cognitive decline in the model with both WMH and FA-Genu. DTI specifically FA-Genu provides unique complementary information to AD biomarkers and has significant utility for prediction of cognitive decline in MCI.
AB - Our goal was to evaluate the utility of diffusion tensor imaging (DTI) for predicting future cognitive decline in mild cognitive impairment (MCI) in conjunction with Alzheimer's disease (AD) biomarkers (amyloid positron emission tomography and AD signature neurodegeneration) in 132 MCI individuals ≥60 year old with structural magnetic resonance imaging, DTI, amyloid positron emission tomography, and at least one clinical follow-up. We used mixed-effect models to evaluate the prognostic ability of fractional anisotropy of the genu of the corpus callosum (FA-Genu), as a cerebrovascular disease marker, for predicting cognitive decline along with AD biomarkers. We contrasted the value of white matter hyperintensities, a traditional cerebrovascular disease marker as well as FA in the hippocampal cingulum bundle with the FA-Genu models. FA-Genu significantly predicted cognitive decline even after accounting for AD biomarkers. WMH was not associated with cognitive decline in the model with both WMH and FA-Genu. DTI specifically FA-Genu provides unique complementary information to AD biomarkers and has significant utility for prediction of cognitive decline in MCI.
KW - Cerebrovascular disease
KW - Diffusion tensor imaging
KW - Genu of the corpus callosum
KW - Mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=85091934023&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85091934023&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2020.09.005
DO - 10.1016/j.neurobiolaging.2020.09.005
M3 - Article
C2 - 33022474
AN - SCOPUS:85091934023
SN - 0197-4580
VL - 96
SP - 176
EP - 183
JO - Neurobiology of aging
JF - Neurobiology of aging
ER -