Reduced fractional anisotropy of the genu of the corpus callosum as a cerebrovascular disease marker and predictor of longitudinal cognition in MCI

Sheelakumari Raghavan, Scott A. Przybelski, Robert I. Reid, Jonathan Graff-Radford, Timothy G. Lesnick, Samantha M. Zuk, David S. Knopman, Mary M. Machulda, Michelle M. Mielke, Ronald C. Petersen, Clifford R. Jack, Prashanthi Vemuri

Research output: Contribution to journalArticlepeer-review

Abstract

Our goal was to evaluate the utility of diffusion tensor imaging (DTI) for predicting future cognitive decline in mild cognitive impairment (MCI) in conjunction with Alzheimer's disease (AD) biomarkers (amyloid positron emission tomography and AD signature neurodegeneration) in 132 MCI individuals ≥60 year old with structural magnetic resonance imaging, DTI, amyloid positron emission tomography, and at least one clinical follow-up. We used mixed-effect models to evaluate the prognostic ability of fractional anisotropy of the genu of the corpus callosum (FA-Genu), as a cerebrovascular disease marker, for predicting cognitive decline along with AD biomarkers. We contrasted the value of white matter hyperintensities, a traditional cerebrovascular disease marker as well as FA in the hippocampal cingulum bundle with the FA-Genu models. FA-Genu significantly predicted cognitive decline even after accounting for AD biomarkers. WMH was not associated with cognitive decline in the model with both WMH and FA-Genu. DTI specifically FA-Genu provides unique complementary information to AD biomarkers and has significant utility for prediction of cognitive decline in MCI.

Original languageEnglish (US)
Pages (from-to)176-183
Number of pages8
JournalNeurobiology of aging
Volume96
DOIs
StatePublished - Dec 2020

Keywords

  • Cerebrovascular disease
  • Diffusion tensor imaging
  • Genu of the corpus callosum
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology

Fingerprint

Dive into the research topics of 'Reduced fractional anisotropy of the genu of the corpus callosum as a cerebrovascular disease marker and predictor of longitudinal cognition in MCI'. Together they form a unique fingerprint.

Cite this