Reduced D2 dopamine and muscarinic cholinergic receptor densities in caudate specimens from fluctuating Parkinsonian patients

J. Eric Ahlskog, Elliott Richelson, Albert Nelson, Patrick J. Kelly, Haruo Okazaki, Gertrude M. Tyce, Jon A. Van Heerden, Susan L. Stoddard, Stephen W. Carmichael

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34 Scopus citations

Abstract

Binding of spiperone and 3-quinuclidinyl benzilate (QNB), both labeled with hydrogen 3 (3H), were measured in caudate tissue obtained from 8 living parkinsonian patients at the time of cerebral transplantation. This was a clinically homogeneous group of patients: All remained predominantly responsive to levodopa, although with marked disability secondary to clinical fluctuations (short-duration responses) and medication-induced dyskinesias; all were receiving substantial doses of levodopa and 6 of the 8 patients were additionally receiving bromocriptine or pergolide. Binding densities of dopamine D2 receptors, as measured by {3H}spiperone binding, were reduced in this group of patients, compared to caudate specimens from autopsy control subjects. This finding may reflect medication-induced receptor downregulation. Parallel changes occurred with muscarinic cholinergic receptors; {3H}QNB binding was significantly reduced, compared to autopsy control values. This reduction of muscarinic receptors might be due to loss of nigrostriatal terminals that are known to contain muscarinic receptors. Alternatively, muscarinic receptors may have been downregulated by increased corticostriatal glutamatergic input to cholinergic cells, inferred to be present based on the prominent levodopa-induced dyskinesias. Finally, receptor deficits could have also been a reflection of more widespread degenerative cerebral disease, although levodopa-refractory symptoms were generally not pronounced in these patients.

Original languageEnglish (US)
Pages (from-to)185-191
Number of pages7
JournalAnnals of Neurology
Volume30
Issue number2
StatePublished - Aug 1991

ASJC Scopus subject areas

  • Neuroscience(all)

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    Ahlskog, J. E., Richelson, E., Nelson, A., Kelly, P. J., Okazaki, H., Tyce, G. M., Van Heerden, J. A., Stoddard, S. L., & Carmichael, S. W. (1991). Reduced D2 dopamine and muscarinic cholinergic receptor densities in caudate specimens from fluctuating Parkinsonian patients. Annals of Neurology, 30(2), 185-191.