Red ginseng inhibits exercise-induced increase in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of rats

Yeong Ki Min, Seok Hee Chung, Jong Soo Lee, Sung Soo Kim, Hyun Dae Shin, Baek Vin Lim, Min Chul Shin, Mi Hyeon Jang, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Red ginseng has been used as an ergogenic aid for endurance exercise. In this study, the effect of aqueous extract of Red ginseng on the endurance in treadmill exercise and 5-hydroxytryptamine (serotonin) synthesis and tryptophan hydroxylase expression in the dorsal raphe of rats were studied. Rats receiving Red ginseng showed increased time to exhaustion for treadmill running, and Red ginseng treatment inhibited exercise-induced increases in 5-hydroxy-tryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe. These results suggest that the suppressive effect of Red ginseng on serotonin level during exercise is a possible ergogenic mechanism of Red ginseng.

Original languageEnglish (US)
Pages (from-to)218-221
Number of pages4
JournalJournal of Pharmacological Sciences
Volume93
Issue number2
DOIs
StatePublished - Oct 1 2003

Keywords

  • Red ginseng
  • Serotonin
  • Treadmill exercise

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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