Red ginseng inhibits exercise-induced increase in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of rats

Yeong Ki Min, Seok Hee Chung, Jong Soo Lee, Sung Soo Kim, Hyun Dae Shin, Baek Vin Lim, Min Chul Shin, Mi-Hyeon D Jang, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Red ginseng has been used as an ergogenic aid for endurance exercise. In this study, the effect of aqueous extract of Red ginseng on the endurance in treadmill exercise and 5-hydroxytryptamine (serotonin) synthesis and tryptophan hydroxylase expression in the dorsal raphe of rats were studied. Rats receiving Red ginseng showed increased time to exhaustion for treadmill running, and Red ginseng treatment inhibited exercise-induced increases in 5-hydroxy-tryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe. These results suggest that the suppressive effect of Red ginseng on serotonin level during exercise is a possible ergogenic mechanism of Red ginseng.

Original languageEnglish (US)
Pages (from-to)218-221
Number of pages4
JournalJournal of Pharmacological Sciences
Volume93
Issue number2
DOIs
StatePublished - Oct 2003
Externally publishedYes

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Tryptophan Hydroxylase
Panax
Serotonin
Running
Dorsal Raphe Nucleus

Keywords

  • Red ginseng
  • Serotonin
  • Treadmill exercise

ASJC Scopus subject areas

  • Pharmacology

Cite this

Red ginseng inhibits exercise-induced increase in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of rats. / Min, Yeong Ki; Chung, Seok Hee; Lee, Jong Soo; Kim, Sung Soo; Shin, Hyun Dae; Lim, Baek Vin; Shin, Min Chul; Jang, Mi-Hyeon D; Kim, Ee Hwa; Kim, Chang Ju.

In: Journal of Pharmacological Sciences, Vol. 93, No. 2, 10.2003, p. 218-221.

Research output: Contribution to journalArticle

Min, Yeong Ki ; Chung, Seok Hee ; Lee, Jong Soo ; Kim, Sung Soo ; Shin, Hyun Dae ; Lim, Baek Vin ; Shin, Min Chul ; Jang, Mi-Hyeon D ; Kim, Ee Hwa ; Kim, Chang Ju. / Red ginseng inhibits exercise-induced increase in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of rats. In: Journal of Pharmacological Sciences. 2003 ; Vol. 93, No. 2. pp. 218-221.
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