Rectal administration of iodide and propylthiouracil in the treatment of thyroid storm

S. C J Yeung, R. Go, A. Balasubramanyam

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We administered potassium iodide and propylthiouracil per rectum, in conjunction with intravenous dexamethasone and propranolol, for emergent treatment of a patient in thyroid storm with small bowel obstruction. Shortly after initiation of this treatment, the patient successfully underwent two emergent surgical procedures for resection of an intestinal volvulus with advanced peritonitis. Serum levels of iodide and propylthiouracil showed substantial absorption of these drugs via the rectal route. Measurement of 24-h urinary-free iodide indicated that the bioavailability of potassium iodide delivered by retention enema was at least 40%. Parenteral iodide preparations have been unavailable in the past, and continue to be difficult to obtain emergently. Rectal administration of inorganic iodide is an effective, readily available and less expensive alternative to parenteral sodium iodide for patients in thyroid storm with upper gastrointestinal tract dysfunction.

Original languageEnglish (US)
Pages (from-to)403-405
Number of pages3
JournalThyroid
Volume5
Issue number5
StatePublished - 1995
Externally publishedYes

Fingerprint

Thyroid Crisis
Rectal Administration
Propylthiouracil
Iodides
Potassium Iodide
Sodium Iodide
Intestinal Volvulus
Upper Gastrointestinal Tract
Enema
Therapeutics
Peritonitis
Rectum
Propranolol
Dexamethasone
Biological Availability
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Endocrinology

Cite this

Yeung, S. C. J., Go, R., & Balasubramanyam, A. (1995). Rectal administration of iodide and propylthiouracil in the treatment of thyroid storm. Thyroid, 5(5), 403-405.

Rectal administration of iodide and propylthiouracil in the treatment of thyroid storm. / Yeung, S. C J; Go, R.; Balasubramanyam, A.

In: Thyroid, Vol. 5, No. 5, 1995, p. 403-405.

Research output: Contribution to journalArticle

Yeung, SCJ, Go, R & Balasubramanyam, A 1995, 'Rectal administration of iodide and propylthiouracil in the treatment of thyroid storm', Thyroid, vol. 5, no. 5, pp. 403-405.
Yeung, S. C J ; Go, R. ; Balasubramanyam, A. / Rectal administration of iodide and propylthiouracil in the treatment of thyroid storm. In: Thyroid. 1995 ; Vol. 5, No. 5. pp. 403-405.
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