Recent advances in clinical practice challenges and opportunities in the management of obesity

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Despite advances in understanding the roles of adiposity, food intake, GI and adipocyte-related hormones, inflammatory mediators, the gut-brain axis and the hypothalamic nervous system in the pathophysiology of obesity, the effects of different therapeutic interventions on those pathophysiological mechanisms are controversial. There are still no low-cost, safe, effective treatments for obesity and its complications. Currently, bariatric surgical approaches targeting the GI tract are more effective than non-surgical approaches in inducing weight reduction and resolving obesity-related comorbidities. However, current guidelines emphasise non-surgical approaches through lifestyle modification and medications to achieve slow weight loss, which is not usually sustained and may be associated with medication-related side effects. This review analyses current central, peripheral or hormonal targets to treat obesity and addresses challenges and opportunities to develop novel approaches for obesity.

Original languageEnglish (US)
Pages (from-to)687-695
Number of pages9
JournalGut
Volume63
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Obesity
Weight Loss
Bariatrics
Adiposity
Therapeutic Uses
Adipocytes
Nervous System
Gastrointestinal Tract
Life Style
Comorbidity
Eating
Hormones
Guidelines
Costs and Cost Analysis
Brain
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Recent advances in clinical practice challenges and opportunities in the management of obesity. / Acosta, Andres; Dayyeh, Barham K Abu; Port, John D; Camilleri, Michael.

In: Gut, Vol. 63, No. 4, 2014, p. 687-695.

Research output: Contribution to journalArticle

@article{131e3674bf5d4b1fa1a40753b5112550,
title = "Recent advances in clinical practice challenges and opportunities in the management of obesity",
abstract = "Despite advances in understanding the roles of adiposity, food intake, GI and adipocyte-related hormones, inflammatory mediators, the gut-brain axis and the hypothalamic nervous system in the pathophysiology of obesity, the effects of different therapeutic interventions on those pathophysiological mechanisms are controversial. There are still no low-cost, safe, effective treatments for obesity and its complications. Currently, bariatric surgical approaches targeting the GI tract are more effective than non-surgical approaches in inducing weight reduction and resolving obesity-related comorbidities. However, current guidelines emphasise non-surgical approaches through lifestyle modification and medications to achieve slow weight loss, which is not usually sustained and may be associated with medication-related side effects. This review analyses current central, peripheral or hormonal targets to treat obesity and addresses challenges and opportunities to develop novel approaches for obesity.",
author = "Andres Acosta and Dayyeh, {Barham K Abu} and Port, {John D} and Michael Camilleri",
year = "2014",
doi = "10.1136/gutjnl-2013-306235",
language = "English (US)",
volume = "63",
pages = "687--695",
journal = "Gut",
issn = "0017-5749",
publisher = "BMJ Publishing Group",
number = "4",

}

TY - JOUR

T1 - Recent advances in clinical practice challenges and opportunities in the management of obesity

AU - Acosta, Andres

AU - Dayyeh, Barham K Abu

AU - Port, John D

AU - Camilleri, Michael

PY - 2014

Y1 - 2014

N2 - Despite advances in understanding the roles of adiposity, food intake, GI and adipocyte-related hormones, inflammatory mediators, the gut-brain axis and the hypothalamic nervous system in the pathophysiology of obesity, the effects of different therapeutic interventions on those pathophysiological mechanisms are controversial. There are still no low-cost, safe, effective treatments for obesity and its complications. Currently, bariatric surgical approaches targeting the GI tract are more effective than non-surgical approaches in inducing weight reduction and resolving obesity-related comorbidities. However, current guidelines emphasise non-surgical approaches through lifestyle modification and medications to achieve slow weight loss, which is not usually sustained and may be associated with medication-related side effects. This review analyses current central, peripheral or hormonal targets to treat obesity and addresses challenges and opportunities to develop novel approaches for obesity.

AB - Despite advances in understanding the roles of adiposity, food intake, GI and adipocyte-related hormones, inflammatory mediators, the gut-brain axis and the hypothalamic nervous system in the pathophysiology of obesity, the effects of different therapeutic interventions on those pathophysiological mechanisms are controversial. There are still no low-cost, safe, effective treatments for obesity and its complications. Currently, bariatric surgical approaches targeting the GI tract are more effective than non-surgical approaches in inducing weight reduction and resolving obesity-related comorbidities. However, current guidelines emphasise non-surgical approaches through lifestyle modification and medications to achieve slow weight loss, which is not usually sustained and may be associated with medication-related side effects. This review analyses current central, peripheral or hormonal targets to treat obesity and addresses challenges and opportunities to develop novel approaches for obesity.

UR - http://www.scopus.com/inward/record.url?scp=84895461525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895461525&partnerID=8YFLogxK

U2 - 10.1136/gutjnl-2013-306235

DO - 10.1136/gutjnl-2013-306235

M3 - Article

C2 - 24402654

AN - SCOPUS:84895461525

VL - 63

SP - 687

EP - 695

JO - Gut

JF - Gut

SN - 0017-5749

IS - 4

ER -