TY - JOUR
T1 - Rebuilding immunity in cancer patients
AU - Vuk-Pavlovic, Stanimir
N1 - Funding Information:
Dedicated to Mrs. Adelyn L. Luther in gratitude for the many years of generous support of Stem Cell Laboratory and in admiration of the breadth of her philanthropic vision. The author thanks Dr. Scott R. Burger for critical reading of the manuscript, Dr. Franklyn G. Prendergast for continuing interest and encouragement and members of Stem Cell Laboratory for many discussions. Author’s work referred to in this paper has been supported in part by the NIH Grant P50CA91956 and Mayo Clinic Cancer Center. This paper is based upon a presentation at the Focused Workshop on Haploidentical Stem Cell Transplantation sponsored by the Leukemia & Lymphoma Society held in Catania, Italy from 4th–6th October, 2007.
PY - 2008/1
Y1 - 2008/1
N2 - Rebuilding and maintaining immunity are paramount to the success of cancer immunotherapy and hematopoietic stem cell transplantation. If immune surveillance indeed can protect from cancer, the very manifestation of malignancy means that the disease has prevailed over immunity. Yet, often, tumor-specific T cells can be found in cancer patients irrespective of vaccination. Interestingly, patients suffering from malignancy often harbor unexpectedly high levels of immature CD14+HLA-DR- monocytes, although the abundance of CD4+ cells, CD8+ cells and CD4+CD25high cells may be normal. It is plausible that in cancer such cells suppress T cell function, analogous to CD14+HLA-DR- cells in sepsis and major trauma, in addition to their likely failure to re-present tumor-associated antigens once dendritic cells have initiated the T cell response. Recent evidence indicates that tumor-borne adenosine, lactate and hypoxia in the tumor environment may modulate tumor-specific immunity to a significant extent, but their effects on myeloid cell function are unclear. Thus, understanding and controlling these factors may appreciably impact the success of rebuilding and maintaining immunity in cancer patients.
AB - Rebuilding and maintaining immunity are paramount to the success of cancer immunotherapy and hematopoietic stem cell transplantation. If immune surveillance indeed can protect from cancer, the very manifestation of malignancy means that the disease has prevailed over immunity. Yet, often, tumor-specific T cells can be found in cancer patients irrespective of vaccination. Interestingly, patients suffering from malignancy often harbor unexpectedly high levels of immature CD14+HLA-DR- monocytes, although the abundance of CD4+ cells, CD8+ cells and CD4+CD25high cells may be normal. It is plausible that in cancer such cells suppress T cell function, analogous to CD14+HLA-DR- cells in sepsis and major trauma, in addition to their likely failure to re-present tumor-associated antigens once dendritic cells have initiated the T cell response. Recent evidence indicates that tumor-borne adenosine, lactate and hypoxia in the tumor environment may modulate tumor-specific immunity to a significant extent, but their effects on myeloid cell function are unclear. Thus, understanding and controlling these factors may appreciably impact the success of rebuilding and maintaining immunity in cancer patients.
UR - http://www.scopus.com/inward/record.url?scp=36749085365&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36749085365&partnerID=8YFLogxK
U2 - 10.1016/j.bcmd.2007.06.025
DO - 10.1016/j.bcmd.2007.06.025
M3 - Article
C2 - 17827037
AN - SCOPUS:36749085365
SN - 1079-9796
VL - 40
SP - 94
EP - 100
JO - Blood Cells, Molecules, and Diseases
JF - Blood Cells, Molecules, and Diseases
IS - 1
ER -