Reactive oxygen species driven angiogenesis by inorganic nanorods

Chitta Ranjan Patra, Jong Ho Kim, Kallal Pramanik, Livius V. D'Uscio, Sujata Patra, Krishnendu Pal, Ramani Ramchandran, Michael S. Strano, Debabrata Mukhopadhyay

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H2O2 and O2·-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H2O2 and a HPLC method for the determination of O2·- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1a:EGFP) zebrafish embryos.

Original languageEnglish (US)
Pages (from-to)4932-4938
Number of pages7
JournalNano Letters
Volume11
Issue number11
DOIs
StatePublished - Nov 9 2011

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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    Patra, C. R., Kim, J. H., Pramanik, K., D'Uscio, L. V., Patra, S., Pal, K., Ramchandran, R., Strano, M. S., & Mukhopadhyay, D. (2011). Reactive oxygen species driven angiogenesis by inorganic nanorods. Nano Letters, 11(11), 4932-4938. https://doi.org/10.1021/nl2028766