Reactive oxygen species driven angiogenesis by inorganic nanorods

Chitta Ranjan Patra; Jong Ho Kim; Kallal Pramanik; Livius V. D'Uscio; Sujata Patra; Krishnendu Pal; Ramani Ramchandran; Michael S. Strano; Debabrata Mukhopadhyay

doi:10.1021/nl2028766

Reactive oxygen species driven angiogenesis by inorganic nanorods

Chitta Ranjan Patra, Jong Ho Kim, Kallal Pramanik, Livius V. D'Uscio, Sujata Patra, Krishnendu Pal, Ramani Ramchandran, Michael S. Strano, Debabrata Mukhopadhyay

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H₂O₂ and O₂·-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H₂O₂ and a HPLC method for the determination of O₂·- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1a:EGFP) zebrafish embryos.

Original language	English (US)
Pages (from-to)	4932-4938
Number of pages	7
Journal	Nano Letters
Volume	11
Issue number	11
DOIs	https://doi.org/10.1021/nl2028766
State	Published - Nov 9 2011

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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title = "Reactive oxygen species driven angiogenesis by inorganic nanorods",

abstract = "The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H2O2 and O2·-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H2O2 and a HPLC method for the determination of O2·- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1a:EGFP) zebrafish embryos.",

author = "Patra, {Chitta Ranjan} and Kim, {Jong Ho} and Kallal Pramanik and D'Uscio, {Livius V.} and Sujata Patra and Krishnendu Pal and Ramani Ramchandran and Strano, {Michael S.} and Debabrata Mukhopadhyay",

year = "2011",

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doi = "10.1021/nl2028766",

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T1 - Reactive oxygen species driven angiogenesis by inorganic nanorods

AU - Patra, Chitta Ranjan

AU - Kim, Jong Ho

AU - Pramanik, Kallal

AU - D'Uscio, Livius V.

AU - Patra, Sujata

AU - Pal, Krishnendu

AU - Ramchandran, Ramani

AU - Strano, Michael S.

AU - Mukhopadhyay, Debabrata

PY - 2011/11/9

Y1 - 2011/11/9

N2 - The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H2O2 and O2·-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H2O2 and a HPLC method for the determination of O2·- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1a:EGFP) zebrafish embryos.

AB - The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H2O2 and O2·-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H2O2 and a HPLC method for the determination of O2·- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (fli1a:EGFP) zebrafish embryos.

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Reactive oxygen species driven angiogenesis by inorganic nanorods

Abstract

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