Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy

Keith A. Josephs; Jennifer L. Whitwell; Bradley F. Boeve; Maria M. Shiung; Jeffrey L. Gunter; Joseph E. Parisi; Dennis W. Dickson; Clifford R. Jack

doi:10.1002/ana.20707

Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy

Keith A. Josephs, Jennifer L. Whitwell, Bradley F. Boeve, Maria M. Shiung, Jeffrey L. Gunter, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Objective: To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods: This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation: These rates provide a benchmark that can be used to monitor future treatment response in PSP.

Original language	English (US)
Pages (from-to)	200-203
Number of pages	4
Journal	Annals of neurology
Volume	59
Issue number	1
DOIs	https://doi.org/10.1002/ana.20707
State	Published - Jan 2006

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy",

abstract = "Objective: To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods: This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation: These rates provide a benchmark that can be used to monitor future treatment response in PSP.",

author = "Josephs, {Keith A.} and Whitwell, {Jennifer L.} and Boeve, {Bradley F.} and Shiung, {Maria M.} and Gunter, {Jeffrey L.} and Parisi, {Joseph E.} and Dickson, {Dennis W.} and Jack, {Clifford R.}",

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AU - Josephs, Keith A.

AU - Whitwell, Jennifer L.

AU - Boeve, Bradley F.

AU - Shiung, Maria M.

AU - Gunter, Jeffrey L.

AU - Parisi, Joseph E.

AU - Dickson, Dennis W.

AU - Jack, Clifford R.

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AB - Objective: To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods: This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation: These rates provide a benchmark that can be used to monitor future treatment response in PSP.

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Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy

Abstract

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