Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy

Keith A. Josephs, Jennifer L. Whitwell, Bradley F. Boeve, Maria M. Shiung, Jeffrey L. Gunter, Joseph E. Parisi, Dennis W. Dickson, Clifford R. Jack

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Objective: To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods: This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age- and sex-matched control subjects. Results: Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation: These rates provide a benchmark that can be used to monitor future treatment response in PSP.

Original languageEnglish (US)
Pages (from-to)200-203
Number of pages4
JournalAnnals of neurology
Volume59
Issue number1
DOIs
StatePublished - Jan 1 2006

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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