Rapidly progressive hippocampal atrophy: Evidence for a seizure-induced mechanism

G. A. Worrell, D. Sencakova, C. R. Jack, K. D. Flemming, J. R. Fulgham, E. L. So

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Hippocampal formation atrophy (HFA) developed in an adult, who did not have epilepsy previously, after the occurrence of new-onset partial seizures from acute thrombosis of an ipsilateral parietal venous angioma. There was no evidence of hippocampal injury, and the patient had only one brief, generalized tonic-clonic seizure. Although HFA progressed rapidly over 5.5 months, the partial seizures did not become prolonged or secondarily generalized. Evidence from the patient indicates that partial seizure activity can cause rapid and progressive hippocampal atrophy.

Original languageEnglish (US)
Pages (from-to)1553-1556
Number of pages4
Issue number10
StatePublished - May 28 2002

ASJC Scopus subject areas

  • Clinical Neurology


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