RAP a novel type of ER chaperone

Guojun D Bu, Alan L. Schwartz

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.

Original languageEnglish (US)
Pages (from-to)272-276
Number of pages5
JournalTrends in Cell Biology
Volume8
Issue number7
DOIs
StatePublished - Dec 1 1998
Externally publishedYes

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Proteins
Molecular Chaperones
LDL Receptors
Secretory Pathway
Ligands
Genes

ASJC Scopus subject areas

  • Cell Biology

Cite this

RAP a novel type of ER chaperone. / Bu, Guojun D; Schwartz, Alan L.

In: Trends in Cell Biology, Vol. 8, No. 7, 01.12.1998, p. 272-276.

Research output: Contribution to journalArticle

Bu, Guojun D ; Schwartz, Alan L. / RAP a novel type of ER chaperone. In: Trends in Cell Biology. 1998 ; Vol. 8, No. 7. pp. 272-276.
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