RAP a novel type of ER chaperone

Guojun Bu; Alan L. Schwartz

doi:10.1016/S0962-8924(98)01283-5

RAP a novel type of ER chaperone

Guojun Bu, Alan L. Schwartz

Neuroscience

Research output: Contribution to journal › Review article › peer-review

87 Scopus citations

Abstract

Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.

Original language	English (US)
Pages (from-to)	272-276
Number of pages	5
Journal	Trends in Cell Biology
Volume	8
Issue number	7
DOIs	https://doi.org/10.1016/S0962-8924(98)01283-5
State	Published - Dec 1 1998

ASJC Scopus subject areas

Cell Biology

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10.1016/S0962-8924(98)01283-5

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title = "RAP a novel type of ER chaperone",

abstract = "Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.",

author = "Guojun Bu and Schwartz, {Alan L.}",

note = "Funding Information: We thank Stuart Kornfeld and Philip Stahl for helpful discussion and reading of the manuscript. Research in the authors' laboratories is supported by grants from NIH, American Cancer Society, Alzheimer's Association and Monsanto.",

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T1 - RAP a novel type of ER chaperone

AU - Bu, Guojun

AU - Schwartz, Alan L.

N1 - Funding Information: We thank Stuart Kornfeld and Philip Stahl for helpful discussion and reading of the manuscript. Research in the authors' laboratories is supported by grants from NIH, American Cancer Society, Alzheimer's Association and Monsanto.

PY - 1998/12/1

Y1 - 1998/12/1

N2 - Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.

AB - Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.

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JO - Trends in Cell Biology

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ER -

RAP a novel type of ER chaperone

Abstract

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