RAP a novel type of ER chaperone

Guojun Bu, Alan L. Schwartz

Research output: Contribution to journalReview article

87 Scopus citations

Abstract

Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.

Original languageEnglish (US)
Pages (from-to)272-276
Number of pages5
JournalTrends in Cell Biology
Volume8
Issue number7
DOIs
StatePublished - Dec 1 1998

ASJC Scopus subject areas

  • Cell Biology

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