TY - JOUR
T1 - Radiopharmaceuticals for positron emission tomography. Development of new, innovative tracers for measuring the rates of physiologic and biochemical processes.
AU - Gatley, S. J.
AU - DeGrado, T. R.
AU - Kornguth, M. L.
AU - Holden, J. E.
PY - 1990
Y1 - 1990
N2 - Positron emission tomography (PET) can give quantitative local information about many processes in the intact human body, which may be useful both for basic studies of metabolic processes in health and disease, and also for diagnostic purposes in individual patients. PET is absolutely limited by the availability of suitable radiotracers. Natural substrates for metabolic processes, e.g. 11C glucose, are not generally useful; compounds with a restricted range of metabolic transformations, all of which can be distinguished kinetically, are better. Radiotracer behavior may then be describable by a fairly simple set of linear first-order rate constants (kinetic model) which can each be determined from PET scan sequences and which can be combined to give physiologically meaningful data. Three 18F compounds, which form a hierarchy of pharmacologic complexity, are briefly described: fluoromethane, for blood flow, 2-deoxy-2-fluoro-D-glucose, for glucose metabolic rates, and 16-fluoropalmitic acid, a candidate tracer for rates of long-chain fatty acid metabolism.
AB - Positron emission tomography (PET) can give quantitative local information about many processes in the intact human body, which may be useful both for basic studies of metabolic processes in health and disease, and also for diagnostic purposes in individual patients. PET is absolutely limited by the availability of suitable radiotracers. Natural substrates for metabolic processes, e.g. 11C glucose, are not generally useful; compounds with a restricted range of metabolic transformations, all of which can be distinguished kinetically, are better. Radiotracer behavior may then be describable by a fairly simple set of linear first-order rate constants (kinetic model) which can each be determined from PET scan sequences and which can be combined to give physiologically meaningful data. Three 18F compounds, which form a hierarchy of pharmacologic complexity, are briefly described: fluoromethane, for blood flow, 2-deoxy-2-fluoro-D-glucose, for glucose metabolic rates, and 16-fluoropalmitic acid, a candidate tracer for rates of long-chain fatty acid metabolism.
UR - http://www.scopus.com/inward/record.url?scp=0025528056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025528056&partnerID=8YFLogxK
M3 - Review article
C2 - 1966972
AN - SCOPUS:0025528056
SN - 0001-6926
VL - 374
SP - 7
EP - 11
JO - Acta radiologica. Supplementum
JF - Acta radiologica. Supplementum
ER -