Radiation-Induced Vascular Disease—A State-of-the-Art Review

Eric H. Yang, Konstantinos Marmagkiolis, Dinu V. Balanescu, Abdul Hakeem, Teodora Donisan, William Finch, Renu Virmani, Joerg Herrman, Mehmet Cilingiroglu, Cindy L. Grines, Konstantinos Toutouzas, Cezar Iliescu

Research output: Contribution to journalReview articlepeer-review


Since the 1990s, there has been a steady increase in the number of cancer survivors to an estimated 17 million in 2019 in the US alone. Radiation therapy today is applied to a variety of malignancies and over 50% of cancer patients. The effects of ionizing radiation on cardiac structure and function, so-called radiation-induced heart disease (RIHD), have been extensively studied. We review the available published data on the mechanisms and manifestations of RIHD, with a focus on vascular disease, as well as proposed strategies for its prevention, screening, diagnosis, and management.

Original languageEnglish (US)
Article number652761
JournalFrontiers in Cardiovascular Medicine
StatePublished - Mar 30 2021


  • cancer
  • cardio-oncology
  • coronary artery disease
  • peripheral arterial disease
  • radiation therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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