RAB39B gene mutations are not a common cause of Parkinson's disease or dementia with Lewy bodies

Kyndall Hodges, Sheridan S. Brewer, Catherine Labbé, Alexandra I. Soto-Ortolaza, Ronald L. Walton, Audrey J. Strongosky, Ryan J. Uitti, Jay A Van Gerpen, Nilufer Taner, Kejal M Kantarci, Val Lowe, Joseph E Parisi, Rodolfo Savica, Jonathan Graff-Radford, David T Jones, David S Knopman, Ronald Carl Petersen, Melissa E Murray, Neill R Graff Radford, Tanis Jill FermanDennis W Dickson, Zbigniew K Wszolek, Bradley F Boeve, Owen A Ross, Oswaldo Lorenzo-Betancor

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Mutations in Ras-related protein Rab-39B (RAB39B) gene have been linked to X-linked early-onset Parkinsonism with intellectual disabilities. The aim of this study was to address the genetic contribution of RAB39B to Parkinson's disease (PD), dementia with Lewy bodies (DLB), and pathologically confirmed Lewy body dementia (pLBD) cases. A cohort of 884 PD, 399 DLB, and 379 pLBD patients were screened for RAB39B mutations, but no coding variants were found, suggesting RAB39B mutations are not a common cause of PD, DLB, or pLBD in Caucasian population.

Original languageEnglish (US)
Pages (from-to)107-108
Number of pages2
JournalNeurobiology of Aging
Volume45
DOIs
StatePublished - Sep 1 2016

Fingerprint

Lewy Body Disease
Parkinson Disease
Mutation
Genes
ras Proteins
Parkinsonian Disorders
Intellectual Disability
Population

Keywords

  • Dementia with Lewy bodies
  • Lewy body dementia
  • Parkinson's disease
  • RAB39B

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Hodges, K., Brewer, S. S., Labbé, C., Soto-Ortolaza, A. I., Walton, R. L., Strongosky, A. J., ... Lorenzo-Betancor, O. (2016). RAB39B gene mutations are not a common cause of Parkinson's disease or dementia with Lewy bodies. Neurobiology of Aging, 45, 107-108. https://doi.org/10.1016/j.neurobiolaging.2016.03.021

RAB39B gene mutations are not a common cause of Parkinson's disease or dementia with Lewy bodies. / Hodges, Kyndall; Brewer, Sheridan S.; Labbé, Catherine; Soto-Ortolaza, Alexandra I.; Walton, Ronald L.; Strongosky, Audrey J.; Uitti, Ryan J.; Van Gerpen, Jay A; Taner, Nilufer; Kantarci, Kejal M; Lowe, Val; Parisi, Joseph E; Savica, Rodolfo; Graff-Radford, Jonathan; Jones, David T; Knopman, David S; Petersen, Ronald Carl; Murray, Melissa E; Graff Radford, Neill R; Ferman, Tanis Jill; Dickson, Dennis W; Wszolek, Zbigniew K; Boeve, Bradley F; Ross, Owen A; Lorenzo-Betancor, Oswaldo.

In: Neurobiology of Aging, Vol. 45, 01.09.2016, p. 107-108.

Research output: Contribution to journalArticle

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