Quantitative imaging of chemical composition using dual-energy, dual-source CT

Xin Liu, Andrew N. Primak, Yu Lifeng, Cynthia H. McCollough, Richard L. Morin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


Dual-energy x-ray material decomposition has been proposed as a noninvasive quantitative imaging technique for more than 20 years. In this paper, we summarize previously developed dual-energy material decomposition methods and propose a simple yet accurate method for quantitatively measuring chemical composition in vivo. In order to take advantage of the newly developed dual-source CT, the proposed method is based upon post reconstruction (image space) data. Different from other post reconstruction methods, this method is designed to directly measure element composition (mass fraction) in a tissue by a simple table lookup procedure. The method has been tested in phantom studies and also applied to a clinical case. The results showed that this method is capable of accurately measuring elemental concentrations, such as iron in tissue, under low noise imaging conditions. The advantage of this method lies in its simplicity and fast processing times. We believe that this method can be applied clinically to measure the mass fraction of any chemical element in a two-material object, such as to quantify the iron overload in the liver (hemochromatosis). Further investigations on de-noising techniques, as well as clinical validation, are merited.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2008 - Physics of Medical Imaging
ISBN (Print)9780819470973
StatePublished - Mar 1 2008
EventMedical Imaging 2008 - Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 18 2008Feb 21 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2008 - Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego, CA


  • Algorithms
  • Computed tomography
  • Dual energy
  • Dual source

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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