Quantification of the relative roles of niche and neutral processes in structuring gastrointestinal microbiomes

Patricio Jeraldo, Maksim Sipos, Nicholas Chia, Jennifer M. Brulc, A. Singh Dhillon, Michael E. Konkel, Charles L. Larson, Karen E. Nelson, Ani Qu, Lawrence B. Schook, Fang Yang, Bryan A. White, Nigel Goldenfeld

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

The theoretical description of the forces that shape ecological communities focuses around two classes of models. In niche theory, deterministic interactions between species, individuals, and the environment are considered the dominant factor,whereas in neutral theory, stochastic forces, such as demographic noise, speciation, and immigration, are dominant. Species abundance distributions predicted by the two classes of theory are difficult to distinguish empirically, making it problematic to deduce ecological dynamics from typical measures of diversity and community structure. Here, we show that the fusion of species abundance data with genome-derived measures of evolutionary distance can provide a clear indication of ecological dynamics, capable of quantifying the relative roles played by niche and neutral forces.We apply this technique to six gastrointestinal microbiomes drawn from three different domesticated vertebrates, using high-resolution surveys of microbial species abundance obtained from carefully curated deep 16S rRNA hypervariable tag sequencing data. Although the species abundance patterns are seemingly well fit by the neutral theory of metacommunity assembly, we show that this theory cannot account for the evolutionary patterns in the genomic data; moreover, our analyses strongly suggest that these microbiomes have, in fact, been assembled through processes that involve a significant nonneutral (niche) contribution. Our results demonstrate that high-resolution genomics can remove the ambiguities of process inference inherent in classic ecologicalmeasures and permits quantification of the forces shaping complex microbial communities.

Original languageEnglish (US)
Pages (from-to)9692-9698
Number of pages7
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number25
DOIs
StatePublished - Jun 19 2012

Keywords

  • Metagenomics
  • Microbial ecology

ASJC Scopus subject areas

  • General

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    Jeraldo, P., Sipos, M., Chia, N., Brulc, J. M., Dhillon, A. S., Konkel, M. E., Larson, C. L., Nelson, K. E., Qu, A., Schook, L. B., Yang, F., White, B. A., & Goldenfeld, N. (2012). Quantification of the relative roles of niche and neutral processes in structuring gastrointestinal microbiomes. Proceedings of the National Academy of Sciences of the United States of America, 109(25), 9692-9698. https://doi.org/10.1073/pnas.1206721109