Putative neuropathological interactions in MSA: Focus in the rostral ventrolateral medulla

E. E. Benarroch, A. M. Schmeichel, Joseph E Parisi, Phillip Anson Low

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We used double immunocytochemistry for α-synuclein and markers of sympathoexcitatory neurons, oligodendrocytes, iron metabolism, and autophagy to study putative neuropathological interactions in multiple system atrophy. We focused in the rostral ventrolateral medulla as a prototype vulnerable region. We found that loss of C1 neurons and oligodendrocytes related to glial cytoplasmic inclusion accumulation, downregulation of iron transport, and upregulation of autophagy and ferritin expression in these area.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalClinical Autonomic Research
Volume25
Issue number1
DOIs
StatePublished - Feb 1 2015

Fingerprint

Oligodendroglia
Autophagy
Iron
Synucleins
Multiple System Atrophy
Neurons
Inclusion Bodies
Ferritins
Neuroglia
Up-Regulation
Down-Regulation
Immunohistochemistry

Keywords

  • Alpha-synuclein
  • Beclin-1
  • Ferroportin
  • Multiple system atrophy

ASJC Scopus subject areas

  • Clinical Neurology
  • Endocrine and Autonomic Systems

Cite this

Putative neuropathological interactions in MSA : Focus in the rostral ventrolateral medulla. / Benarroch, E. E.; Schmeichel, A. M.; Parisi, Joseph E; Low, Phillip Anson.

In: Clinical Autonomic Research, Vol. 25, No. 1, 01.02.2015, p. 77-80.

Research output: Contribution to journalArticle

Benarroch, E. E. ; Schmeichel, A. M. ; Parisi, Joseph E ; Low, Phillip Anson. / Putative neuropathological interactions in MSA : Focus in the rostral ventrolateral medulla. In: Clinical Autonomic Research. 2015 ; Vol. 25, No. 1. pp. 77-80.
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