Putative neuropathological interactions in MSA: Focus in the rostral ventrolateral medulla

E. E. Benarroch, A. M. Schmeichel, Joseph E Parisi, Phillip Anson Low

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We used double immunocytochemistry for α-synuclein and markers of sympathoexcitatory neurons, oligodendrocytes, iron metabolism, and autophagy to study putative neuropathological interactions in multiple system atrophy. We focused in the rostral ventrolateral medulla as a prototype vulnerable region. We found that loss of C1 neurons and oligodendrocytes related to glial cytoplasmic inclusion accumulation, downregulation of iron transport, and upregulation of autophagy and ferritin expression in these area.

Original languageEnglish (US)
Pages (from-to)77-80
Number of pages4
JournalClinical Autonomic Research
Volume25
Issue number1
DOIs
StatePublished - Feb 1 2015

Keywords

  • Alpha-synuclein
  • Beclin-1
  • Ferroportin
  • Multiple system atrophy

ASJC Scopus subject areas

  • Clinical Neurology
  • Endocrine and Autonomic Systems

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