Pure Autonomic Failure

Research output: Contribution to journalReview article

Abstract

Pure autonomic failure (PAF) is a neurodegenerative disorder of the autonomic nervous system clinically characterized by orthostatic hypotension. The disorder has also been known as Bradbury-Eggleston syndrome, named for the authors of the 1925 seminal description. Patients typically present in midlife or later with orthostatic hypotension or syncope. Autonomic failure may also manifest as genitourinary, bowel, and thermoregulatory dysfunction. With widespread involvement, patients may present to a variety of different specialties and require multidisciplinary treatment approaches. Pathologically, PAF is characterized by predominantly peripheral deposition of α-synuclein. However, patients with PAF may progress into other synucleinopathies with central nervous system involvement.

Original languageEnglish (US)
Pages (from-to)2087-2098
Number of pages12
JournalMayo Clinic proceedings
Volume94
Issue number10
DOIs
StatePublished - Oct 1 2019

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Pure Autonomic Failure
Orthostatic Hypotension
Autonomic Nervous System Diseases
Synucleins
Syncope
Neurodegenerative Diseases
Central Nervous System

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pure Autonomic Failure. / Coon, Elizabeth; Singer, Wolfgang; Low, Phillip Anson.

In: Mayo Clinic proceedings, Vol. 94, No. 10, 01.10.2019, p. 2087-2098.

Research output: Contribution to journalReview article

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