Pure Autonomic Failure

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Pure autonomic failure (PAF) is a neurodegenerative disorder of the autonomic nervous system clinically characterized by orthostatic hypotension. The disorder has also been known as Bradbury-Eggleston syndrome, named for the authors of the 1925 seminal description. Patients typically present in midlife or later with orthostatic hypotension or syncope. Autonomic failure may also manifest as genitourinary, bowel, and thermoregulatory dysfunction. With widespread involvement, patients may present to a variety of different specialties and require multidisciplinary treatment approaches. Pathologically, PAF is characterized by predominantly peripheral deposition of α-synuclein. However, patients with PAF may progress into other synucleinopathies with central nervous system involvement.

Original languageEnglish (US)
Pages (from-to)2087-2098
Number of pages12
JournalMayo Clinic proceedings
Issue number10
StatePublished - Oct 2019

ASJC Scopus subject areas

  • Medicine(all)


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