TY - JOUR
T1 - Pulsatility of hypothalamo-pituitary hormones
T2 - A challenge in quantification
AU - Keenan, Daniel M.
AU - Veldhuis, Johannes D.
N1 - Publisher Copyright:
© 2016 Int. Union Physiol. Sci./Am. Physiol. Soc.
PY - 2016/1
Y1 - 2016/1
N2 - Neuroendocrine systems control many of the most fundamental physiological processes, e.g., reproduction, growth, adaptations to stress, and metabolism. Each such system involves the hypothalamus, the pituitary, and a specific target gland or organ. In the quantification of the interactions among these components, biostatistical modeling has played an important role. In the present article, five key challenges to an understanding of the interactions of these systems are illustrated and discussed critically.
AB - Neuroendocrine systems control many of the most fundamental physiological processes, e.g., reproduction, growth, adaptations to stress, and metabolism. Each such system involves the hypothalamus, the pituitary, and a specific target gland or organ. In the quantification of the interactions among these components, biostatistical modeling has played an important role. In the present article, five key challenges to an understanding of the interactions of these systems are illustrated and discussed critically.
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U2 - 10.1152/physiol.00027.2015
DO - 10.1152/physiol.00027.2015
M3 - Review article
C2 - 26674550
AN - SCOPUS:84949939577
SN - 1548-9213
VL - 31
SP - 34
EP - 50
JO - Physiology
JF - Physiology
IS - 1
ER -