Pulsatile release patterns of luteinizing hormone and progesterone in relation to symptom onset in women with premenstrual syndrome

L. L. Lewis, E. M. Greenblatt, C. A. Rittenhouse, Johannes D Veldhuis, R. B. Jaffe

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Objective: To explore the pulsatile-release characteristics of LH and P in women with premenstrual syndrome (PMS) compared with age-matched phase- matched controls. Design: Prospective, repeated measures, two-group study. Setting: Human volunteers in an academic research environment. Participants: Six women with rigorously defined prospectively determined PMS; six age- matched phase-matched controls. Main Outcome Measures: Frequency, amplitude, concentration, and coincident pulsatile release characteristics of LH and P at three symptom-related points of the luteal phase. Results: No significant between-group differences in frequency, amplitude, or concentration were found. In pooled data, significant coincident pulsing between LH and P was demonstrated. The length of time between LH and P pulses systematically increased across the luteal phase, a finding not previously reported. In the PMS group only, significant coincident pulsing occurred at an unexpected zero time lag on the symptom-onset sampling day. Conclusion: A progressively increasing coupling interval may reflect the gradual decline of the corpus luteum. Presence of a zero time lag between LH and P at symptom onset in women with PMS may indicate an aberrance in corpus luteum response to LH stimulation.

Original languageEnglish (US)
Pages (from-to)288-292
Number of pages5
JournalFertility and Sterility
Volume64
Issue number2
StatePublished - 1995
Externally publishedYes

Keywords

  • luteinizing hormone
  • Premenstrual syndrome
  • progesterone; coincident pulsatility

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Lewis, L. L., Greenblatt, E. M., Rittenhouse, C. A., Veldhuis, J. D., & Jaffe, R. B. (1995). Pulsatile release patterns of luteinizing hormone and progesterone in relation to symptom onset in women with premenstrual syndrome. Fertility and Sterility, 64(2), 288-292.