Pulmonary symptoms measured by the national institutes of health lung score predict overall survival, nonrelapse mortality, and patient-reported outcomes in chronic graft-versus-host disease

Jeanne Palmer, Kirsten Williams, Yoshihiro Inamoto, Xiaoyu Chai, Paul J. Martin, Linus Santo Tomas, Corey Cutler, Daniel Weisdorf, Brenda F. Kurland, Paul A. Carpenter, Joseph Pidala, Steven Z. Pavletic, William Wood, David Jacobsohn, Sally Arai, Mukta Arora, Madan Jagasia, Georgia B. Vogelsang, Stephanie J. Lee

Research output: Contribution to journalArticle

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Abstract

The 2005 National Institutes of Health (NIH) Consensus Conference recommended assessment of lung function in patients with chronic graft-versus-host disease (GVHD) by both pulmonary function tests (PFTs) and assessment of pulmonary symptoms. We tested whether pulmonary measures were associated with nonrelapse mortality (NRM), overall survival (OS), and patient-reported outcomes (PRO). Clinician and patient-reported data were collected serially in a prospective, multicenter, observational study. Available PFT data were abstracted. Cox regression models were fit for outcomes using a time-varying covariate model for lung function measures and adjusting for patient and transplantation characteristics and nonlung chronic GVHD severity. A total of 1591 visits (496 patients) were used in this analysis. The NIH symptom-based lung score was associated with NRM (P= .02), OS (P= .02), patient-reported symptoms (P < .001) and functional status (P < .001). Worsening of NIH symptom-based lung score over time was associated with higher NRM and lower survival. All other measures were not associated with OS or NRM; although, some were associated with patient-reported lung symptoms. In conclusion, the NIH symptom-based lung symptom score of 0 to 3 is associated with NRM, OS, and PRO measures in patients with chronic GVHD. Worsening of the NIH symptom-based lung score was associated with increased mortality.

Original languageEnglish (US)
Pages (from-to)337-344
Number of pages8
JournalBiology of Blood and Marrow Transplantation
Volume20
Issue number3
DOIs
StatePublished - Mar 1 2014
Externally publishedYes

Fingerprint

National Institutes of Health (U.S.)
Graft vs Host Disease
Lung
Survival
Mortality
Respiratory Function Tests
Patient Reported Outcome Measures
Symptom Assessment
Proportional Hazards Models
Multicenter Studies
Observational Studies
Transplantation

Keywords

  • Bronchiolitis obliterans syndrome
  • Chronic graft-versus-host disease

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Pulmonary symptoms measured by the national institutes of health lung score predict overall survival, nonrelapse mortality, and patient-reported outcomes in chronic graft-versus-host disease. / Palmer, Jeanne; Williams, Kirsten; Inamoto, Yoshihiro; Chai, Xiaoyu; Martin, Paul J.; Tomas, Linus Santo; Cutler, Corey; Weisdorf, Daniel; Kurland, Brenda F.; Carpenter, Paul A.; Pidala, Joseph; Pavletic, Steven Z.; Wood, William; Jacobsohn, David; Arai, Sally; Arora, Mukta; Jagasia, Madan; Vogelsang, Georgia B.; Lee, Stephanie J.

In: Biology of Blood and Marrow Transplantation, Vol. 20, No. 3, 01.03.2014, p. 337-344.

Research output: Contribution to journalArticle

Palmer, J, Williams, K, Inamoto, Y, Chai, X, Martin, PJ, Tomas, LS, Cutler, C, Weisdorf, D, Kurland, BF, Carpenter, PA, Pidala, J, Pavletic, SZ, Wood, W, Jacobsohn, D, Arai, S, Arora, M, Jagasia, M, Vogelsang, GB & Lee, SJ 2014, 'Pulmonary symptoms measured by the national institutes of health lung score predict overall survival, nonrelapse mortality, and patient-reported outcomes in chronic graft-versus-host disease', Biology of Blood and Marrow Transplantation, vol. 20, no. 3, pp. 337-344. https://doi.org/10.1016/j.bbmt.2013.11.025
Palmer, Jeanne ; Williams, Kirsten ; Inamoto, Yoshihiro ; Chai, Xiaoyu ; Martin, Paul J. ; Tomas, Linus Santo ; Cutler, Corey ; Weisdorf, Daniel ; Kurland, Brenda F. ; Carpenter, Paul A. ; Pidala, Joseph ; Pavletic, Steven Z. ; Wood, William ; Jacobsohn, David ; Arai, Sally ; Arora, Mukta ; Jagasia, Madan ; Vogelsang, Georgia B. ; Lee, Stephanie J. / Pulmonary symptoms measured by the national institutes of health lung score predict overall survival, nonrelapse mortality, and patient-reported outcomes in chronic graft-versus-host disease. In: Biology of Blood and Marrow Transplantation. 2014 ; Vol. 20, No. 3. pp. 337-344.
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AU - Inamoto, Yoshihiro

AU - Chai, Xiaoyu

AU - Martin, Paul J.

AU - Tomas, Linus Santo

AU - Cutler, Corey

AU - Weisdorf, Daniel

AU - Kurland, Brenda F.

AU - Carpenter, Paul A.

AU - Pidala, Joseph

AU - Pavletic, Steven Z.

AU - Wood, William

AU - Jacobsohn, David

AU - Arai, Sally

AU - Arora, Mukta

AU - Jagasia, Madan

AU - Vogelsang, Georgia B.

AU - Lee, Stephanie J.

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