Pulmonary regurgitation after tetralogy of fallot repair: Clinical features, sequelae, and timing of pulmonary valve replacement

Naser M. Ammash, Joseph A. Dearani, Harold M. Burkhart, Heidi M. Connolly

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Pulmonary regurgitation following repair of tetralogy of Fallot is a common postoperative sequela associated with progressive right ventricular enlargement, dysfunction, and is an important determinant of late morbidity and mortality. Although pulmonary regurgitation may be well tolerated for many years following surgery, it can be associated with progressive exercise intolerance, heart failure, tachyarrhythmia, and late sudden death. It also often necessitates re-intervention. Identifying the appropriate timing of such intervention could be very challenging given the risk of prosthetic valve degeneration and the increased risk of reoperation. Comprehensive informed and regular assessment of the postoperative patient with tetralogy of Fallot, including evaluation of pulmonary regurgitation, right heart structure and function, is crucial to the optimal care of these patients. Pulmonary valve replacement performed in an experienced tertiary referral center is associated with low operative morbidity and mortality and very good long-term results. Early results of percutaneous pulmonary valve replacement are also promising.

Original languageEnglish (US)
Pages (from-to)386-403
Number of pages18
JournalCongenital Heart Disease
Volume2
Issue number6
DOIs
StatePublished - Nov 1 2007

Keywords

  • Congenital Heart Disease
  • Pulmonary Regurgitation
  • Tetralogy of Fallot

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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