Pulmonary disorders: Ventilation-perfusion MR imaging with animal models

Qun Chen; David L. Levín; Ducksoo Kim; Vivek David; Michelle McNicholas; Victoria Chen; Peter M. Jakob; Mark A. Griswold; James W. Goldfarb; Hiroto Hatabu; Robert R. Edelman

doi:10.1148/radiology.213.3.r99dc31871

Pulmonary disorders: Ventilation-perfusion MR imaging with animal models

Qun Chen, David L. Levín, Ducksoo Kim, Vivek David, Michelle McNicholas, Victoria Chen, Peter M. Jakob, Mark A. Griswold, James W. Goldfarb, Hiroto Hatabu, Robert R. Edelman

Radiology

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

PURPOSE: To demonstrate the capability of magnetic resonance (MR) imaging to assess alteration in regional pulmonary ventilation and perfusion with animal models of airway obstruction and pulmonary embolism. MATERIALS AND METHODS: Airway obstruction was created by inflating a 5-F balloon catheter into a secondary bronchus. Pulmonary emboli were created by injecting thrombi into the inferior vena cava. Regional pulmonary ventilation was assessed with 100% oxygen as a T1 contrast agent. Regional pulmonary perfusion was assessed with a two-dimensional fast low-angle shot, or FLASH, sequence with short repetition and echo times after intravenous administration of gadopentetate dimeglumine. RESULTS: Matched ventilation and perfusion abnormalities were identified in all animals with airway obstruction. MR perfusion defects without ventilation abnormalities were seen in all animals with pulmonary emboli. CONCLUSION: Ventilation and perfusion MR imaging are able to provide regional pulmonary functional information with high spatial and temporal resolution. The ability of MR imaging to assess both the magnitude and regional distribution of pulmonary functional impairment could have an important effect on the evaluation of lung disease.

Original language	English (US)
Pages (from-to)	871-879
Number of pages	9
Journal	Radiology
Volume	213
Issue number	3
DOIs	https://doi.org/10.1148/radiology.213.3.r99dc31871
State	Published - Dec 1999

Keywords

Bronchi, stenosis or obstruction
Embolism, experimental studies
Gadolinium
Lung, MR
Lung, perfusion
Lung, ventilation
Oxygen

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/radiology.213.3.r99dc31871

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title = "Pulmonary disorders: Ventilation-perfusion MR imaging with animal models",

abstract = "PURPOSE: To demonstrate the capability of magnetic resonance (MR) imaging to assess alteration in regional pulmonary ventilation and perfusion with animal models of airway obstruction and pulmonary embolism. MATERIALS AND METHODS: Airway obstruction was created by inflating a 5-F balloon catheter into a secondary bronchus. Pulmonary emboli were created by injecting thrombi into the inferior vena cava. Regional pulmonary ventilation was assessed with 100% oxygen as a T1 contrast agent. Regional pulmonary perfusion was assessed with a two-dimensional fast low-angle shot, or FLASH, sequence with short repetition and echo times after intravenous administration of gadopentetate dimeglumine. RESULTS: Matched ventilation and perfusion abnormalities were identified in all animals with airway obstruction. MR perfusion defects without ventilation abnormalities were seen in all animals with pulmonary emboli. CONCLUSION: Ventilation and perfusion MR imaging are able to provide regional pulmonary functional information with high spatial and temporal resolution. The ability of MR imaging to assess both the magnitude and regional distribution of pulmonary functional impairment could have an important effect on the evaluation of lung disease.",

keywords = "Bronchi, stenosis or obstruction, Embolism, experimental studies, Gadolinium, Lung, MR, Lung, perfusion, Lung, ventilation, Oxygen",

author = "Qun Chen and Lev{\'i}n, {David L.} and Ducksoo Kim and Vivek David and Michelle McNicholas and Victoria Chen and Jakob, {Peter M.} and Griswold, {Mark A.} and Goldfarb, {James W.} and Hiroto Hatabu and Edelman, {Robert R.}",

year = "1999",

month = dec,

doi = "10.1148/radiology.213.3.r99dc31871",

language = "English (US)",

volume = "213",

pages = "871--879",

journal = "Radiology",

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T2 - Ventilation-perfusion MR imaging with animal models

AU - Chen, Qun

AU - Levín, David L.

AU - Kim, Ducksoo

AU - David, Vivek

AU - McNicholas, Michelle

AU - Chen, Victoria

AU - Jakob, Peter M.

AU - Griswold, Mark A.

AU - Goldfarb, James W.

AU - Hatabu, Hiroto

AU - Edelman, Robert R.

PY - 1999/12

Y1 - 1999/12

N2 - PURPOSE: To demonstrate the capability of magnetic resonance (MR) imaging to assess alteration in regional pulmonary ventilation and perfusion with animal models of airway obstruction and pulmonary embolism. MATERIALS AND METHODS: Airway obstruction was created by inflating a 5-F balloon catheter into a secondary bronchus. Pulmonary emboli were created by injecting thrombi into the inferior vena cava. Regional pulmonary ventilation was assessed with 100% oxygen as a T1 contrast agent. Regional pulmonary perfusion was assessed with a two-dimensional fast low-angle shot, or FLASH, sequence with short repetition and echo times after intravenous administration of gadopentetate dimeglumine. RESULTS: Matched ventilation and perfusion abnormalities were identified in all animals with airway obstruction. MR perfusion defects without ventilation abnormalities were seen in all animals with pulmonary emboli. CONCLUSION: Ventilation and perfusion MR imaging are able to provide regional pulmonary functional information with high spatial and temporal resolution. The ability of MR imaging to assess both the magnitude and regional distribution of pulmonary functional impairment could have an important effect on the evaluation of lung disease.

AB - PURPOSE: To demonstrate the capability of magnetic resonance (MR) imaging to assess alteration in regional pulmonary ventilation and perfusion with animal models of airway obstruction and pulmonary embolism. MATERIALS AND METHODS: Airway obstruction was created by inflating a 5-F balloon catheter into a secondary bronchus. Pulmonary emboli were created by injecting thrombi into the inferior vena cava. Regional pulmonary ventilation was assessed with 100% oxygen as a T1 contrast agent. Regional pulmonary perfusion was assessed with a two-dimensional fast low-angle shot, or FLASH, sequence with short repetition and echo times after intravenous administration of gadopentetate dimeglumine. RESULTS: Matched ventilation and perfusion abnormalities were identified in all animals with airway obstruction. MR perfusion defects without ventilation abnormalities were seen in all animals with pulmonary emboli. CONCLUSION: Ventilation and perfusion MR imaging are able to provide regional pulmonary functional information with high spatial and temporal resolution. The ability of MR imaging to assess both the magnitude and regional distribution of pulmonary functional impairment could have an important effect on the evaluation of lung disease.

KW - Bronchi, stenosis or obstruction

KW - Embolism, experimental studies

KW - Gadolinium

KW - Lung, MR

KW - Lung, perfusion

KW - Lung, ventilation

KW - Oxygen

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Pulmonary disorders: Ventilation-perfusion MR imaging with animal models

Abstract

Keywords

ASJC Scopus subject areas

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