TY - JOUR
T1 - Psychosis associated to Parkinson's disease in the early stages
T2 - Relevance of cognitive decline and depression
AU - PRIAMO Study Group
AU - Morgante, Letterio
AU - Colosimo, Carlo
AU - Antonini, Angelo
AU - Marconi, Roberto
AU - Meco, Giuseppe
AU - Pederzoli, Massimo
AU - Pontieri, Francesco E.
AU - Cicarelli, Giulio
AU - Abbruzzese, Giovanni
AU - Zappulla, Salvatore
AU - Ramat, Silvia
AU - Manfredi, Michela
AU - Bottacchi, Edo
AU - Abrignani, Michele
AU - Berardelli, Alfredo
AU - Cozzolino, Autilia
AU - Paradiso, Claudio
AU - De Gaspari, Danilo
AU - Morgante, Francesca
AU - Barone, Paolo
AU - Caravona, N.
AU - Braga, M.
AU - Pellicano, C.
AU - Petretta, V.
AU - Di Brigida, G.
AU - Meoni, S.
AU - Pepe, F.
AU - Di Giovanni, M.
AU - Modica, C.
AU - Mucchiut, M.
AU - Bartalini, S.
AU - Cossu, G.
AU - Pennisi, F.
AU - Bartolomei, L.
AU - L'Erario, R.
AU - Tiple, D.
AU - Petrone, A.
AU - Avarello, T. P.
AU - Bentivoglio, A. R.
AU - Scala, R.
AU - Gaglio, R. M.
AU - Giglia, L.
AU - Ceravolo, R.
AU - Nicoletti, A.
AU - Trianni, G.
AU - Martinelli, P.
AU - Rocco, M.
AU - Moschella, V.
AU - Volpe, G.
AU - Savica, R.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Objective: To evaluate the prevalence of psychosis associated with Parkinson's disease (PSY-PD) in its early stages, its incidence over a 24 month follow-up period and the association with motor and non-motor clinical features. Methods: PRIAMO is a 2 year longitudinal observational study that has enrolled patients with parkinsonism in 55 Italian centres. A cohort of 495 patients with early disease stage PD (baseline Hoehn and Yahr score ≤2, disease's duration (median) 3.4 years) were followed for 2 years. PSY-PD was evaluated by means of a clinician rated questionnaire and defined as the presence of at least one of the following symptoms occurring for at least 1 month: illusions, hallucinations, jealousy ideas and persecutory ideas. Patients with and without PSY-PD were compared on several clinical variables, encompassing motor and non-motor features. Results: The prevalence of PSY-PD at baseline was 3%; the incidences at 12 and 24 months were 5.2% and 7.7%, respectively. Longer disease duration and prescription of dopamine agonists at baseline were associated with the development of PSY-PD over the 24 month period. At this follow-up time, worse disease severity, decline in cognitive performances, presence of depressive symptoms and anxiety were more frequently observed in PSY-PD. Conclusions: Psychotic type symptoms may occur in the early stages of PD although less frequently than in later stages. Beyond dopaminergic treatment, there are disease related factors, such as disease severity and the occurrence of cognitive and depressive symptoms, which may underlie the onset of psychotic type symptoms from the earliest stages.
AB - Objective: To evaluate the prevalence of psychosis associated with Parkinson's disease (PSY-PD) in its early stages, its incidence over a 24 month follow-up period and the association with motor and non-motor clinical features. Methods: PRIAMO is a 2 year longitudinal observational study that has enrolled patients with parkinsonism in 55 Italian centres. A cohort of 495 patients with early disease stage PD (baseline Hoehn and Yahr score ≤2, disease's duration (median) 3.4 years) were followed for 2 years. PSY-PD was evaluated by means of a clinician rated questionnaire and defined as the presence of at least one of the following symptoms occurring for at least 1 month: illusions, hallucinations, jealousy ideas and persecutory ideas. Patients with and without PSY-PD were compared on several clinical variables, encompassing motor and non-motor features. Results: The prevalence of PSY-PD at baseline was 3%; the incidences at 12 and 24 months were 5.2% and 7.7%, respectively. Longer disease duration and prescription of dopamine agonists at baseline were associated with the development of PSY-PD over the 24 month period. At this follow-up time, worse disease severity, decline in cognitive performances, presence of depressive symptoms and anxiety were more frequently observed in PSY-PD. Conclusions: Psychotic type symptoms may occur in the early stages of PD although less frequently than in later stages. Beyond dopaminergic treatment, there are disease related factors, such as disease severity and the occurrence of cognitive and depressive symptoms, which may underlie the onset of psychotic type symptoms from the earliest stages.
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U2 - 10.1136/jnnp-2011-300043
DO - 10.1136/jnnp-2011-300043
M3 - Article
C2 - 21836035
AN - SCOPUS:84155172794
SN - 0022-3050
VL - 83
SP - 76
EP - 82
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
IS - 1
ER -