TY - JOUR
T1 - Pseudoangiomatous stromal hyperplasia and breast cancer risk
AU - Degnim, Amy C.
AU - Frost, Marlene H.
AU - Radisky, Derek C.
AU - Anderson, Stephanie S.
AU - Vierkant, Robert A.
AU - Boughey, Judy C.
AU - Shane Pankratz, V.
AU - Ghosh, Karthik
AU - Hartmann, Lynn C.
AU - Visscher, Daniel W.
N1 - Funding Information:
ACKNOWLEDGMENT Amy C. Degnim is supported by the CA90628-08 Paul Calabresi Award for Clinical-Translational Research (K12) via the Mayo Clinic Cancer Center. Lynn C. Hart-mann and V. Shane Pankratz are supported in part by R01CA132879. We thank Teresa Allers, Jo Johnson, Mary Campion, Melanie Kasner, and Romayne Thompson for data collection; Joel Worra for database development; Ann Harris and the Survey Research Center for patient follow-up; and Marilyn Churchward for assistance with manuscript preparation.
PY - 2010/12
Y1 - 2010/12
N2 - Background: Pseudoangiomatous stromal hyperplasia (PASH) is a benign localized fibrotic lesion in which clusters of spindle cells form cleftlike spaces, resembling ectatic vessels. Its relationship to breast cancer risk has not been characterized. Materials and Methods: Histological presence of PASH was evaluated by review of archival slides in a single institution cohort of women who underwent benign excisional breast biopsy from 1967 to 1991. Relative risks for subsequent breast cancer were estimated using standardized incidence ratios (SIR), comparing the observed number of cancers with those expected based on Iowa SEER data (mean follow-up 18.5 years). Results: PASH was identified in 579 of 9065 biopsies (6.4%). Women with PASH were younger, more likely to have a palpable mass as indication for biopsy, and had less lobular involution compared with those without PASH (all P < 0.001), while they did not differ by family history of breast cancer or degree of epithelial proliferation. Breast cancers occurred in 34 women with PASH (5.9%) and 789 without (8.8%). Women with PASH had lower risk of breast cancer (SIR 1.03, 95% confidence interval [95% CI] 0.71-1.44) than those without PASH (SIR 1.54, 95% CI 1.43-1.65), P = 0.01. Lower levels of breast cancer risk for the PASH group persisted in analyses stratified by age, family history, epithelial proliferation, and involution. The cancers in the PASH group occurred predominantly in the ipsilateral breast more than 5 years after biopsy. Conclusions: Despite clinical concern generated by palpable density often associated with PASH, this relatively uncommon histological finding does not connote increased risk of subsequent breast cancer.
AB - Background: Pseudoangiomatous stromal hyperplasia (PASH) is a benign localized fibrotic lesion in which clusters of spindle cells form cleftlike spaces, resembling ectatic vessels. Its relationship to breast cancer risk has not been characterized. Materials and Methods: Histological presence of PASH was evaluated by review of archival slides in a single institution cohort of women who underwent benign excisional breast biopsy from 1967 to 1991. Relative risks for subsequent breast cancer were estimated using standardized incidence ratios (SIR), comparing the observed number of cancers with those expected based on Iowa SEER data (mean follow-up 18.5 years). Results: PASH was identified in 579 of 9065 biopsies (6.4%). Women with PASH were younger, more likely to have a palpable mass as indication for biopsy, and had less lobular involution compared with those without PASH (all P < 0.001), while they did not differ by family history of breast cancer or degree of epithelial proliferation. Breast cancers occurred in 34 women with PASH (5.9%) and 789 without (8.8%). Women with PASH had lower risk of breast cancer (SIR 1.03, 95% confidence interval [95% CI] 0.71-1.44) than those without PASH (SIR 1.54, 95% CI 1.43-1.65), P = 0.01. Lower levels of breast cancer risk for the PASH group persisted in analyses stratified by age, family history, epithelial proliferation, and involution. The cancers in the PASH group occurred predominantly in the ipsilateral breast more than 5 years after biopsy. Conclusions: Despite clinical concern generated by palpable density often associated with PASH, this relatively uncommon histological finding does not connote increased risk of subsequent breast cancer.
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U2 - 10.1245/s10434-010-1170-5
DO - 10.1245/s10434-010-1170-5
M3 - Article
C2 - 20567920
AN - SCOPUS:78650965784
SN - 1068-9265
VL - 17
SP - 3269
EP - 3277
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 12
ER -