Proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response

Vinuth N. Puttamallesh, Sreelakshmi K. Sreenivasamurthy, Pradeep Kumar Singh, H. C. Harsha, Anjali Ganjiwale, Shobha Broor, Akhilesh Pandey, Jayasuryan Narayana, T. S.Keshava Prasad

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: Chikungunya is a highly debilitating febrile illness caused by Chikungunya virus, a single-stranded RNA virus, which is transmitted by Aedes aegypti or Aedes albopictus mosquito species. The pathogenesis and host responses in individuals infected with the chikungunya virus are not well understood at the molecular level. We carried out proteomic profiling of serum samples from chikungunya patients in order to identify molecules associated with the host response to infection by this virus. Results: Proteomic profiling of serum obtained from the infected individuals resulted in identification of 569 proteins. Of these, 63 proteins were found to be differentially expressed (≥ 2-fold) in patient as compared to control sera. These differentially expressed proteins were involved in various processes such as lipid metabolism, immune response, transport, signal transduction and apoptosis. Conclusions: This is the first report providing a global proteomic profile of serum samples from individuals infected with the chikungunya virus. Our data provide an insight into the proteins that are involved as host response factors during an infection. These proteins include clusterin, apolipoproteins and S100A family of proteins.

Original languageEnglish (US)
Article number14
JournalClinical Proteomics
Volume10
Issue number1
DOIs
StatePublished - 2013

Keywords

  • Arthritis
  • Hyponatremia
  • Itraq
  • Neuropathology
  • Quantitative proteomics

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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    Puttamallesh, V. N., Sreenivasamurthy, S. K., Singh, P. K., Harsha, H. C., Ganjiwale, A., Broor, S., Pandey, A., Narayana, J., & Prasad, T. S. K. (2013). Proteomic profiling of serum samples from chikungunya-infected patients provides insights into host response. Clinical Proteomics, 10(1), [14]. https://doi.org/10.1186/1559-0275-10-14