Protein nutrition and malnutrition in CKD and ESRD

Yan Zha, Qi Qian

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Elevated protein catabolism and protein malnutrition are common in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). The underlying etiology includes, but is not limited to, metabolic acidosis intestinal dysbiosis; systemic inflammation with activation of complements, endothelin-1 and renin-angiotensin-aldosterone (RAAS) axis; anabolic hormone resistance; energy expenditure elevation; and uremic toxin accumulation. All of these derangements can further worsen kidney function, leading to poor patient outcomes. Many of these CKD-related derangements can be prevented and substantially reversed, representing an area of great potential to improve CKD and ESRD care. This review integrates known information and recent advances in the area of protein nutrition and malnutrition in CKD and ESRD. Management recommendations are summarized. Thorough understanding the pathogenesis and etiology of protein malnutrition in CKD and ESRD patients will undoubtedly facilitate the design and development of more effective strategies to optimize protein nutrition and improve outcomes.

Original languageEnglish (US)
Article number208
JournalNutrients
Volume9
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

kidney diseases
Chronic Renal Insufficiency
Malnutrition
malnutrition
Chronic Kidney Failure
nutrition
Proteins
proteins
Dysbiosis
kwashiorkor
Complement C1
Angiotensins
Endothelin-1
Acidosis
Aldosterone
Renin
etiology
Energy Metabolism
Hormones
angiotensins

Keywords

  • Acidosis
  • Chronic kidney disease
  • Dialysis
  • Hormonal derangements
  • Inflammation
  • Protein catabolism
  • Protein nutrition
  • Uremic toxins

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Protein nutrition and malnutrition in CKD and ESRD. / Zha, Yan; Qian, Qi.

In: Nutrients, Vol. 9, No. 3, 208, 01.03.2017.

Research output: Contribution to journalReview article

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