Protein kinase D enzymes: Novel kinase targets in pancreatic cancer

Geou Yarh Liou, Peter Storz

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDA) is characterized by advanced stage desmoplastic tumors with a high prevalence of genetic abnormalities. Occurrence of PDA is linked to activating Kras mutations and aberrant epidermal growth factor receptor signaling, leading to additional activation of wild-type Kras. As Kras is difficult to target, there is a constant need to identify novel targets acting downstream of this molecule in driving the formation or progression of PDA. Recently, it was shown that protein kinase D enzymes not only are increasingly expressed in PDA but also causatively linked to the development and progression of this cancer. They act downstream of both mutant Kras and growth factors and therefore may represent ideal novel targets.

Original languageEnglish (US)
Pages (from-to)1143-1146
Number of pages4
JournalExpert Review of Gastroenterology and Hepatology
Volume9
Issue number9
DOIs
StatePublished - Sep 2 2015

Keywords

  • Acinar-to-ductal metaplasia
  • Isoforms
  • Pancreatic cancer
  • Protein kinase D

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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