Prostate cancer incidence in males with Lynch syndrome

Sigurdis Haraldsdottir, Heather Hampel, Lai Wei, Christina Wu, Wendy Frankel, Tanios Bekaii-Saab, Albert De La Chapelle, Richard M. Goldberg

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Purpose:An increased risk of prostate cancer is currently not considered a part of the Lynch syndrome spectrum. The purpose of this study was to retrospectively examine prostate cancer incidence in the Lynch syndrome cohort at the Ohio State University in comparison with that in the general population.Methods:We included all males diagnosed with Lynch syndrome from June 1998 to June 2012 at the Ohio State University and obtained baseline information including cancer history. If patients had not been seen in the 12 months before June 2012, they were contacted to document changes in their cancer history. We compared prostate cancer incidence among the Lynch syndrome families with that of the general population by using the Surveillance, Epidemiology, and End Results registry 1999-2009.Results:Of the 188 males identified with Lynch syndrome, 11 males were diagnosed with prostate cancer during the study period. The ratio of observed to expected numbers of prostate cancer cases resulted in a standardized rate ratio of 4.87 (95% confidence interval: 2.43-8.71). Impaired mismatch repair expression and microsatellite instability were seen in one out of two prostate cancer specimens available for testing.Conclusion:Males with Lynch syndrome had a nearly fivefold increased risk of developing prostate cancer but did not appear to have earlier onset or a more aggressive phenotype.Genet Med 16 7, 553-557.

Original languageEnglish (US)
Pages (from-to)553-557
Number of pages5
JournalGenetics in Medicine
Volume16
Issue number7
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Hereditary Nonpolyposis Colorectal Neoplasms
Prostatic Neoplasms
Incidence
Population Surveillance
Viverridae
Microsatellite Instability
DNA Mismatch Repair
Registries
Neoplasms
Epidemiology
Confidence Intervals
Phenotype

Keywords

  • Colorectal cancer
  • Lynch syndrome
  • Microsatellite instability
  • Mismatch repair deficiency
  • Prostate cancer

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Haraldsdottir, S., Hampel, H., Wei, L., Wu, C., Frankel, W., Bekaii-Saab, T., ... Goldberg, R. M. (2014). Prostate cancer incidence in males with Lynch syndrome. Genetics in Medicine, 16(7), 553-557. https://doi.org/10.1038/gim.2013.193

Prostate cancer incidence in males with Lynch syndrome. / Haraldsdottir, Sigurdis; Hampel, Heather; Wei, Lai; Wu, Christina; Frankel, Wendy; Bekaii-Saab, Tanios; De La Chapelle, Albert; Goldberg, Richard M.

In: Genetics in Medicine, Vol. 16, No. 7, 01.01.2014, p. 553-557.

Research output: Contribution to journalArticle

Haraldsdottir, S, Hampel, H, Wei, L, Wu, C, Frankel, W, Bekaii-Saab, T, De La Chapelle, A & Goldberg, RM 2014, 'Prostate cancer incidence in males with Lynch syndrome', Genetics in Medicine, vol. 16, no. 7, pp. 553-557. https://doi.org/10.1038/gim.2013.193
Haraldsdottir S, Hampel H, Wei L, Wu C, Frankel W, Bekaii-Saab T et al. Prostate cancer incidence in males with Lynch syndrome. Genetics in Medicine. 2014 Jan 1;16(7):553-557. https://doi.org/10.1038/gim.2013.193
Haraldsdottir, Sigurdis ; Hampel, Heather ; Wei, Lai ; Wu, Christina ; Frankel, Wendy ; Bekaii-Saab, Tanios ; De La Chapelle, Albert ; Goldberg, Richard M. / Prostate cancer incidence in males with Lynch syndrome. In: Genetics in Medicine. 2014 ; Vol. 16, No. 7. pp. 553-557.
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