TY - JOUR
T1 - Prosodic and phonetic subtypes of primary progressive apraxia of speech
AU - Utianski, Rene L.
AU - Duffy, Joseph R.
AU - Clark, Heather M.
AU - Strand, Edythe A.
AU - Botha, Hugo
AU - Schwarz, Christopher G.
AU - Machulda, Mary M.
AU - Senjem, Matthew L.
AU - Spychalla, Anthony J.
AU - Jack, Clifford R.
AU - Petersen, Ronald C.
AU - Lowe, Val J.
AU - Whitwell, Jennifer L.
AU - Josephs, Keith A.
N1 - Funding Information:
The study was funded by NIH grants R01 DC010367 (PI: Josephs), R21 NS94684 (PI: Josephs), R01 DC12519 (PI: Whitwell), R01 DC014942 (PI: Josephs), R01 AG11378 (PI: Jack), U01 AG006786 (PI: Petersen), The Elsie and Marvin Dekelboum Family Foundation, and a grant from the Department of Radiology, Mayo Clinic .
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/9
Y1 - 2018/9
N2 - Primary progressive apraxia of speech (PPAOS) is a clinical syndrome in which apraxia of speech is the initial indication of neurodegenerative disease. Prior studies of PPAOS have identified hypometabolism, grey matter atrophy, and white matter tract degeneration in the frontal gyri, precentral cortex, and supplementary motor area (SMA). Recent clinical observations suggest two distinct subtypes of PPAOS may exist. Phonetic PPAOS is characterized predominantly by distorted sound substitutions. Prosodic PPAOS is characterized predominantly by slow, segmented speech. Demographic, clinical, and neuroimaging data (MRI, DTI, and FDG-PET) were analyzed to validate these subtypes and explore anatomic correlates. The Phonetic subtype demonstrated bilateral involvement of the SMA, precentral gyrus, and cerebellar crus. The Prosodic subtype demonstrated more focal involvement in the SMA and right superior cerebellar peduncle. The findings provide converging evidence that differences in the reliably determined predominant clinical characteristics of AOS are associated with distinct imaging patterns, independent of severity.
AB - Primary progressive apraxia of speech (PPAOS) is a clinical syndrome in which apraxia of speech is the initial indication of neurodegenerative disease. Prior studies of PPAOS have identified hypometabolism, grey matter atrophy, and white matter tract degeneration in the frontal gyri, precentral cortex, and supplementary motor area (SMA). Recent clinical observations suggest two distinct subtypes of PPAOS may exist. Phonetic PPAOS is characterized predominantly by distorted sound substitutions. Prosodic PPAOS is characterized predominantly by slow, segmented speech. Demographic, clinical, and neuroimaging data (MRI, DTI, and FDG-PET) were analyzed to validate these subtypes and explore anatomic correlates. The Phonetic subtype demonstrated bilateral involvement of the SMA, precentral gyrus, and cerebellar crus. The Prosodic subtype demonstrated more focal involvement in the SMA and right superior cerebellar peduncle. The findings provide converging evidence that differences in the reliably determined predominant clinical characteristics of AOS are associated with distinct imaging patterns, independent of severity.
KW - Diffusion tensor imaging
KW - Magnetic resonance imaging
KW - Positron-emission tomography
KW - Primary progressive aphasia
KW - Primary progressive apraxia of speech
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U2 - 10.1016/j.bandl.2018.06.004
DO - 10.1016/j.bandl.2018.06.004
M3 - Article
C2 - 29980072
AN - SCOPUS:85049301830
SN - 0093-934X
VL - 184
SP - 54
EP - 65
JO - Brain and Language
JF - Brain and Language
ER -