Prosodic and phonetic subtypes of primary progressive apraxia of speech

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Primary progressive apraxia of speech (PPAOS) is a clinical syndrome in which apraxia of speech is the initial indication of neurodegenerative disease. Prior studies of PPAOS have identified hypometabolism, grey matter atrophy, and white matter tract degeneration in the frontal gyri, precentral cortex, and supplementary motor area (SMA). Recent clinical observations suggest two distinct subtypes of PPAOS may exist. Phonetic PPAOS is characterized predominantly by distorted sound substitutions. Prosodic PPAOS is characterized predominantly by slow, segmented speech. Demographic, clinical, and neuroimaging data (MRI, DTI, and FDG-PET) were analyzed to validate these subtypes and explore anatomic correlates. The Phonetic subtype demonstrated bilateral involvement of the SMA, precentral gyrus, and cerebellar crus. The Prosodic subtype demonstrated more focal involvement in the SMA and right superior cerebellar peduncle. The findings provide converging evidence that differences in the reliably determined predominant clinical characteristics of AOS are associated with distinct imaging patterns, independent of severity.

Original languageEnglish (US)
Pages (from-to)54-65
Number of pages12
JournalBrain and Language
Volume184
DOIs
StatePublished - Sep 1 2018

Fingerprint

Apraxias
Phonetics
phonetics
Motor Cortex
Frontal Lobe
Apraxia of Speech
Neuroimaging
substitution
Neurodegenerative Diseases
Atrophy
indication
Demography
Disease

Keywords

  • Diffusion tensor imaging
  • Magnetic resonance imaging
  • Positron-emission tomography
  • Primary progressive aphasia
  • Primary progressive apraxia of speech

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Language and Linguistics
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

Cite this

Prosodic and phonetic subtypes of primary progressive apraxia of speech. / Utianski, Rene; Duffy, Joseph R.; Clark, Heather; Strand, Edythe A.; Botha, Hugo; Schwarz, Christopher; Machulda, Mary Margaret; Senjem, Matthew L.; Spychalla, Anthony J.; Jack, Clifford R Jr.; Petersen, Ronald Carl; Lowe, Val; Whitwell, Jennifer Lynn; Josephs, Keith Anthony.

In: Brain and Language, Vol. 184, 01.09.2018, p. 54-65.

Research output: Contribution to journalArticle

@article{999a962e672449f6bded3a5dfdee7af6,
title = "Prosodic and phonetic subtypes of primary progressive apraxia of speech",
abstract = "Primary progressive apraxia of speech (PPAOS) is a clinical syndrome in which apraxia of speech is the initial indication of neurodegenerative disease. Prior studies of PPAOS have identified hypometabolism, grey matter atrophy, and white matter tract degeneration in the frontal gyri, precentral cortex, and supplementary motor area (SMA). Recent clinical observations suggest two distinct subtypes of PPAOS may exist. Phonetic PPAOS is characterized predominantly by distorted sound substitutions. Prosodic PPAOS is characterized predominantly by slow, segmented speech. Demographic, clinical, and neuroimaging data (MRI, DTI, and FDG-PET) were analyzed to validate these subtypes and explore anatomic correlates. The Phonetic subtype demonstrated bilateral involvement of the SMA, precentral gyrus, and cerebellar crus. The Prosodic subtype demonstrated more focal involvement in the SMA and right superior cerebellar peduncle. The findings provide converging evidence that differences in the reliably determined predominant clinical characteristics of AOS are associated with distinct imaging patterns, independent of severity.",
keywords = "Diffusion tensor imaging, Magnetic resonance imaging, Positron-emission tomography, Primary progressive aphasia, Primary progressive apraxia of speech",
author = "Rene Utianski and Duffy, {Joseph R.} and Heather Clark and Strand, {Edythe A.} and Hugo Botha and Christopher Schwarz and Machulda, {Mary Margaret} and Senjem, {Matthew L.} and Spychalla, {Anthony J.} and Jack, {Clifford R Jr.} and Petersen, {Ronald Carl} and Val Lowe and Whitwell, {Jennifer Lynn} and Josephs, {Keith Anthony}",
year = "2018",
month = "9",
day = "1",
doi = "10.1016/j.bandl.2018.06.004",
language = "English (US)",
volume = "184",
pages = "54--65",
journal = "Brain and Language",
issn = "0093-934X",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Prosodic and phonetic subtypes of primary progressive apraxia of speech

AU - Utianski, Rene

AU - Duffy, Joseph R.

AU - Clark, Heather

AU - Strand, Edythe A.

AU - Botha, Hugo

AU - Schwarz, Christopher

AU - Machulda, Mary Margaret

AU - Senjem, Matthew L.

AU - Spychalla, Anthony J.

AU - Jack, Clifford R Jr.

AU - Petersen, Ronald Carl

AU - Lowe, Val

AU - Whitwell, Jennifer Lynn

AU - Josephs, Keith Anthony

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Primary progressive apraxia of speech (PPAOS) is a clinical syndrome in which apraxia of speech is the initial indication of neurodegenerative disease. Prior studies of PPAOS have identified hypometabolism, grey matter atrophy, and white matter tract degeneration in the frontal gyri, precentral cortex, and supplementary motor area (SMA). Recent clinical observations suggest two distinct subtypes of PPAOS may exist. Phonetic PPAOS is characterized predominantly by distorted sound substitutions. Prosodic PPAOS is characterized predominantly by slow, segmented speech. Demographic, clinical, and neuroimaging data (MRI, DTI, and FDG-PET) were analyzed to validate these subtypes and explore anatomic correlates. The Phonetic subtype demonstrated bilateral involvement of the SMA, precentral gyrus, and cerebellar crus. The Prosodic subtype demonstrated more focal involvement in the SMA and right superior cerebellar peduncle. The findings provide converging evidence that differences in the reliably determined predominant clinical characteristics of AOS are associated with distinct imaging patterns, independent of severity.

AB - Primary progressive apraxia of speech (PPAOS) is a clinical syndrome in which apraxia of speech is the initial indication of neurodegenerative disease. Prior studies of PPAOS have identified hypometabolism, grey matter atrophy, and white matter tract degeneration in the frontal gyri, precentral cortex, and supplementary motor area (SMA). Recent clinical observations suggest two distinct subtypes of PPAOS may exist. Phonetic PPAOS is characterized predominantly by distorted sound substitutions. Prosodic PPAOS is characterized predominantly by slow, segmented speech. Demographic, clinical, and neuroimaging data (MRI, DTI, and FDG-PET) were analyzed to validate these subtypes and explore anatomic correlates. The Phonetic subtype demonstrated bilateral involvement of the SMA, precentral gyrus, and cerebellar crus. The Prosodic subtype demonstrated more focal involvement in the SMA and right superior cerebellar peduncle. The findings provide converging evidence that differences in the reliably determined predominant clinical characteristics of AOS are associated with distinct imaging patterns, independent of severity.

KW - Diffusion tensor imaging

KW - Magnetic resonance imaging

KW - Positron-emission tomography

KW - Primary progressive aphasia

KW - Primary progressive apraxia of speech

UR - http://www.scopus.com/inward/record.url?scp=85049301830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049301830&partnerID=8YFLogxK

U2 - 10.1016/j.bandl.2018.06.004

DO - 10.1016/j.bandl.2018.06.004

M3 - Article

C2 - 29980072

AN - SCOPUS:85049301830

VL - 184

SP - 54

EP - 65

JO - Brain and Language

JF - Brain and Language

SN - 0093-934X

ER -